Liposome Analysis and Characterization

Liposomes are widely recognized as a prominent drug delivery system due to their remarkable versatility and ability to offer protection for encapsulated drugs, thereby enhancing stability and preventing degradation. To ensure the optimal functionality of liposomes as carriers of bioactive substances, it is imperative to thoroughly characterize their properties, including size, layering, surface charge, quantitative composition, and encapsulation rate. Common techniques employed for the analysis and characterization of liposomes encompass 31P nuclear magnetic resonance (NMR) (utilized for studying membrane fluidity and thermal phase transitions), dynamic light scattering (DLS), atomic force microscopy (AFM), fluorescence spectroscopy, high-performance liquid chromatography (HPLC), capillary electrophoresis (CE), among others. CD Formulation employs diverse methodologies to assist customers in characterizing liposomal solutions and drug-carrying liposomes.

Fig.1 Liposome Analysis and Characterization. (Danielle E. Large, et al., 2021)

The Importance of Liposome Analysis and Characterization

The properties specific to liposome-based drug products, such as their composition, size, and preparation techniques, are crucial quality attributes. Physicochemical properties like size distribution and morphology also play a significant role in determining the overall stability and efficacy of liposomes as drug carriers. Other key attributes include payload, encapsulation efficiency, bilayer structure, and biological characteristics. Accurate measurement of these parameters is critical for early drug development and quality control of new products. Furthermore, these parameters greatly influence the bioactivity and biodistribution of liposome-based drug and gene delivery platforms. Therefore, employing analytical techniques that provide objective and reliable information about the characteristics of liposome particles can significantly enhance the product development process while reducing time required for ensuring final quality.

Our Services for Liposome Analysis and Characterization

The study of liposome quality characterization and critical quality attributes (CQAs) can be utilized for formulation process screening and stability testing, as well as serving as a reference and foundation for subsequent non-clinical research leading to clinical application. CD Formulation, a specialized nanoformulation service company, focuses on the development, manufacturing, analysis, and evaluation of liposome formulations. With extensive experience in liposome development, analysis, and evaluation spanning many years, our services encompass various aspects of liposomal characterization including but not limited to:

Our Platforms for Liposome Analysis and Characterization

Highlights for 0ur Liposome Analysis and Characterization Services

• Expertise. We have established a dedicated liposome characterization platform, and our team can support a variety of liposome characterization services, including physical and chemical properties, stability assessment, in vitro and in vivo release analysis, etc., to ensure that our customers get the most accurate and reliable results.
• Extensive and comprehensive. Our liposome characterization services support the detection and analysis of various liposome formulations, including, ophthalmic liposomes, transdermal liposomes, injectable liposomes, lyophilized liposomes and more.
• Multiple analysis methods. We can develop a variety of detection methods, and combine a variety of detection methods to verify each other, aiming to provide high sensitivity, high accuracy and high repeatability analysis results.

CD Formulation has accumulated extensive expertise and experience in the characterization of liposomes, with a specific focus on understanding the unique characteristics exhibited by different types of liposomes. Our highly skilled research team, comprising experienced professionals, has been at the forefront of this cutting-edge research for numerous years, consistently dedicated to providing comprehensive solutions tailored to our clients' needs. Should you require any assistance, please do not hesitate to contact us promptly.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.