Liposome Aerosol Characterization
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CD Formulation Liposomal encapsulated drugs can be released continuously in the lung after inhalation, thus prolonging the treatment time and reducing the frequency of administration. In addition, the slow release of the drug in the lung reduces the irritation to lung tissue. In addition, inhaled liposomes can also be used for mRNA delivery. Inhalable liposome drugs can be inhaled by means of atomization and powder inhalation. The CD Formulation provides professional liposome characterization services for inhalation
Why You Need Liposome Aerosol Characterization?
Aerosol delivery of liposomes has many applications in the medical field, mainly in the treatment of respiratory diseases. It is an effective way to deliver anti-inflammatory and anti-fibrotic drugs to treat chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). It is also used to deliver antibiotics to treat lung infections, anti-cancer agents for lung cancer and gene therapy agents for cystic fibrosis. Therefore, the liposome aerosol characterization is increasingly important.
Fig.1 Schematic illustration mechanism of atomization technology of atomized liposomes. (Bernhard Lehofer, et al., 2023)
Explore Our Services for Liposome Aerosol Characterization
Our services focus on the stability of aerosols, as well as the assessment of the efficacy and stability after spraying. The specific content is as follows:
Atomization Rate Analysis
Flow rate assessment of quantitative inhalation aerosols (MDI) and SMI spray inhalers, oral inhalation product testing, and delivery dose uniformity testing (DDU).
Aerosol Droplet Size Distribution
At this service, we offer aerodynamic particle size distribution, spray pattern and spray pattern.
Size & Encapsulation rate of Encapsulated Drug After atomization
At this service, we provide the uniformity of particle size distribution and the change of encapsulation rate of liposomes after atomization to provide a reference for the stability of atomizer.
Our Platforms for Liposome Aerosol Characterization
| Platforms |
Specifics |
| In vitro Evaluation Platform |
Our in vitro evaluation methods mainly include the following three aspects: delivery dose and delivery dose uniformity, aerodynamic particle size distribution, spray mode and spray form. |
| In vivo evaluation Evaluation Platform |
At present, there are two main methods for in vivo evaluation of inhaled agents: pharmacokinetic study and radionuclide imaging. |
Highlights for Liposome Aerosol Characterization
- Cutting-edge facility. Our platform is equipped with various cutting-edge equipment to meet liposome aerosol characterization including different nebulizer devices to assess the aerodynamic performance of liposome formulations. We also equip other analytical instruments, such as photon correlation spectroscopy for particle size, laser doppler micro-electrophoresis for size distribution and zeta potential, etc.
- Advanced. Our state-of-the-art equipment and advanced methodologies of liposome aerosol characterization enable us to deliver precise and reproducible results, ensuring that our clients receive the most accurate and reliable data to support their research and development initiatives.
- Comprehensive. With our expertise in nanotechnology and aerosol characterization, we are committed to partnering with our clients to drive innovation and advance the field of nanomedicine, cosmetics, and environmental sciences.
Published Data
Technology: abbreviated cascade impactor technology
Journal: International Journal of Pharmaceutics
IF: 10.5
Published: 2018
Results: In this study, the author studied the influence of probe ultrasonic processing as a size reduction method on the incorporation of drugs into liposomes, as well as the properties of aerosols generated by jet and vibrating mesh nebulizers. The use of next-generation impactors (NGI) was limited by the need for precise quantification of 8 stages of drug deposition in inhaler formulations, and required a significant amount of labor. The FSI, which contains two impact stages, was compared to the NGI to evaluate its suitability as a simple screening and labor-saving tool for characterizing nebulization systems. For the developed lipid formulations, the fine particle fraction (FPF) generated by the jet nebulizer was twice that of the vibrating mesh nebulizer. The study results show that the cooling FSI (5°C) operating at 15 L/min can effectively distinguish the aerosol characteristics of the studied liposomal formulations. Overall, according to the measurements using the abbreviated impactor, in 10 minutes, jet nebulization is more effective than vibrating mesh nebulization in delivering optimized co-loaded liposomes.
CD Formulation comprehensive Liposome Aerosol Characterization services are designed to provide a detailed understanding of the physical and chemical properties of liposome aerosols. These services are tailored to meet the needs of researchers and developers working in the fields of pharmaceutical, biotechnology, and nanotechnology. Please do not hesitate to contact us promptly should you require any form of assistance.
References
- Bernhard Lehofer, Florian Bloder,et al. Impact of atomization technique on the stability and transport efficiency of nebulized liposomes harboring different surface characteristics. European Journal of Pharmaceutics and Biopharmaceutics, 2014; Volume 88, Issue 3.
- Nimmano N, Somavarapu S, et al. Aerosol characterisation of nebulised liposomes co-loaded with erlotinib and genistein using an abbreviated cascade impactor method. Int J Pharm. 2018; 542(1-2): 8-17.
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