Mass Spectrometry (MS) Platform for Nucleic Acid Drugs

CD Formulation's MS technology platform has been refined over the years to establish a premier mass spectrometry structure characterization platform for nucleic acid formulations. We offer a comprehensive array of mass spectrometry testing technologies to support the early discovery of nucleic acid drugs, process development...

Classification of Mass Spectrometry Platforms

Mass spectrometry (MS) is an analytical technique that employs the mass-to-charge ratio (m/z) to identify compounds within a sample. The mass spectrometer ionizes the sample into gaseous ions and subsequently identifies these ions based on their mass-to-charge ratio and relative abundance. Below are the various types of mass spectrometry platforms available.

Electrospray Ionization Mass Spectrometry (ESI-MS)

ESI-MS technique offers highly accurate mass determination, facilitating precise identification and quantitative analysis of nucleic acid sequences and their modifications.

Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS)

MALDI-MS offers the advantages of speed, efficiency, and the requirement of only a small sample size.

Tandem Mass Spectrometry (MS/MS)

In nucleic acid analysis, tandem mass spectrometry (MS/MS) can be employed to analyze the sequences of nucleic acid fragments, detect modifications, and identify specific structural domains.

Ion Mobility Spectrometry-Mass Spectrometry (IMS-MS)

In nucleic acid research, IMS-MS can be employed to detect and characterize the tertiary structure of nucleic acids and their interactions with proteins or other molecules.

Quadrupole Mass Spectrometry (Quadrupole MS)

In nucleic acid analysis, quadrupole MS can be employed to accurately quantify specific nucleic acid fragments, detect low-abundance mutations, and analyze nucleic acid metabolites.

Fig.1 Advantages of mass spectrometry technology platforms. (CD Formulation)

Types of Technologies Integrated with Mass Spectrometry Platforms

Our Core Capabilities of Mass Spectrometry Platforms

CD Formulation offers a mass spectrometry platform that specializes in structural characterization, quality attribute studies, process impurity characterization, and product release analysis of nucleic acid formulations. This ensures high-quality standards for nucleic acid drugs throughout all stages of development and manufacturing.

Structural Characterization of Nucleic Acid Formulations

The mass spectrometry platform facilitates detailed structural characterization of nucleic acid formulations at various stages of development, revealing their quality attributes through mass spectrometry. This process is essential for ensuring consistently high quality in nucleic acid formulations throughout development and production, and it also enables consistent quality comparisons between batches.

Establishing Qualitative and Quantitative Methods

Our mass spectrometry platform is committed to developing and optimizing both qualitative and quantitative mass spectrometry methods to accurately identify and measure key quality attributes of nucleic acid formulations. This approach not only enhances analytical precision and reliability but also fosters innovation in the field of nucleic acid formulations.

Characterization of Impurities

Mass spectrometry platforms are extensively utilized to identify and characterize both process-related and product-related impurities during the development of nucleic acid formulations. This approach aids in optimizing the production process and ensuring product purity and safety, thereby meeting stringent production standards.

Analytical Method Development

The mass spectrometry platform offers comprehensive analytical method services for the identification and release of nucleic acids. Mass spectrometry techniques are developed, optimized, and evaluated to ensure that nucleic acid formulations meet all predetermined criteria before release.

Highlights of Mass Spectrometry Technology Platforms

• The MS platform is highly effective at detecting and differentiating compounds with closely related molecular weights. This technique is particularly sensitive, allowing for the detection of target molecules even at very low concentrations of nucleic acids within the sample.
• The MS platform offers highly accurate molecular weight information, which is essential for structural identification, sequence analysis, and the verification of chemical modifications in nucleic acid drugs.
• Tandem MS platforms facilitate the acquisition of detailed structural information about nucleic acid drugs, including the identification of specific modification sites and residues.
• The MS platform not only qualitatively analyzes nucleic acid drugs but also provides precise quantitative data, which is critical for drug discovery and development, particularly in determining dosage and concentration-related studies.

Our Analytical Characterization Services

CD Formulation's MS platform offers advanced analytical capabilities for the identification of nucleic acid drug molecules, impurity analysis, and other related fields. We can provide professional data and technical support to our customers.

Publication Data

CD Formulation provides advanced mass spectrometry platforms, including LC-MS, GC-MS, and MALDI-TOF MS. These platforms deliver high sensitivity and resolution, enabling accurate qualitative and quantitative analysis of chemical components in complex samples. Contact us for a professional solution tailored to your project.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.