Technologies & Platforms

Start Your Project Now!

Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.

Here's how you can reach us...

Tel:
Email:

Liposome Drug Delivery System Platform

Inquiry

CD Formulation's liposome drug delivery platform offers a comprehensive, one-stop service for developing drug delivery systems. Our platform efficiently synthesizes lipids, prepares liposomes, optimizes and develops processes, researches quality, evaluates safety, and more.

About Liposome Synthesis Technology

Items	Descriptions
Solvent Injection Method	This straightforward technique for creating liposomes involves dissolving lipids in an organic solvent and injecting the drug into this mixture at a regulated pace to form liposomes.
Thin Film Dispersion Method	This method involves dissolving drugs and lipids in an organic solvent, then using a rotary evaporator to remove the solvent under reduced pressure, forming a thin lipid layer. Adding an aqueous medium hydrates and separates the film to produce drug-laden liposomes.
Reverse Phase Evaporation Method	This approach mixes a lipid-containing organic solution with a drug-containing aqueous solution via sonication to create W/O emulsions. Liposomes result from evaporating the mixture under reduced pressure, suitable for water-soluble drugs and large molecules.
Extrusion Method	Liposomes undergo external pressure, squeezing through a filter with pore sizes smaller than the liposomes. This shearing force deforms and ruptures the liposomes, which then quickly reform into smaller units.
Microfluidic Technology	This method offers fast and efficient liposome production by controlling microfluid flow and mixing within channels, resulting in precise and uniform liposomes.

Our Solutions of Liposome Drug Delivery System Platform

Nucleic Acid Stability Assurance

We employ advanced technologies to protect the integrity and activity of nucleic acids during delivery, preventing degradation in both in vivo and ex vivo environments. Our approach ensures that nucleic acid components maintain effective biological activity before reaching target cells.

Efficient Delivery Mechanisms

To enhance nucleic acid drug delivery efficiency, we design various liposome structures to optimize the delivery process. By adjusting the particle size, surface charge, and encapsulation rate of liposomes, we can significantly improve the cellular uptake of nucleic acids.

Customized Solutions

CD Formulation offers not only standardized products but also personalized customization options designed for different nucleic acid drugs. We optimize lipid and nucleic acid combinations according to specific therapeutic needs to achieve more precise drug action.

Rigorous Quality and Safety Evaluation

We provide a complete quality control and safety evaluation system for liposomal nucleic acid drugs. This includes thorough testing from nucleic acid purity to liposome characteristics, ensuring each drug meets the highest standards.

Our Instrument Platform

TEM Platform

TEM enables visualization of liposomes, emphasizing their morphology and structure. While cryo-TEM is the best choice, negative staining offers a simpler, faster method. Notably, liposome shape may deform during staining and drying.

Confocal Microscope Platform

By labeling the lipid bilayer with fluorescent markers, the structure of liposomes can be studied in confocal images, allowing non-destructive 3D image reconstruction. It is a good technique for evaluating internal structures of large multilayer vesicles; however, it cannot resolve structures below 200nm, like small unilamellar vesicles.

HPLC Platform

This equipment offers high-throughput analytical capability, aiding in calculating the encapsulation efficiency (EE) of liposomes. Even without any purification of liposomes (e.g., SEC, dialysis), EE can still be assessed using HPLC. The technology also monitors storage stability related to leakage or the impact of various disruptive conditions on encapsulated materials.

Highlights of Our Liposome Drug Delivery Platform

Our platform offers comprehensive technical integration services, covering all stages from nucleic acid design to final product validation, ensuring efficient progression and successful commercialization of each drug project.
With strong customization capabilities, the platform can flexibly adjust and optimize delivery parameters to meet the unique needs of different therapeutic regimens, ensuring the maximum drug effect and patient safety.
By utilizing advanced data analysis and simulation tools, the platform can accurately predict the performance of nucleic acid drugs in various biological environments, providing reliable basis for strategic adjustments and decision-making.
Our platform features a professional interdisciplinary team, capable of rapidly responding to R&D bottlenecks and market changes, offering clients innovative solutions and competitive advantages.

Services Provided by Our Liposome Drug Delivery Platform

Physicochemical Characterization

Our platform conducts comprehensive characterization of liposome products, including particle size distribution, surface charge, and encapsulation rate, ensuring stability.

Stability Analysis

We conduct extensive studies on stability and storage conditions, assisting clients in determining the best preservation methods, extending the shelf life of products.

Publication Data

Technology: Liposome-assisted drug delivery platform for encapsulating drugs

Journal: Frontiers in pharmacology

IF: 4.4

Published: 2024

Results:

Liposomes enhance the stabilization of therapeutic compounds, aiding cellular and tissue uptake while improving biodistribution at target sites in vivo. They enable efficient delivery of encapsulated compounds and reduce systemic toxicity. Their flexible physicochemical and biophysical properties make them an appealing delivery system for various needs. This review will address advancements and ongoing biological challenges in liposome-assisted drug delivery.

Fig.1 Diagrammatic illustration of various liposomal drug delivery system types. Fig.1 Schematic representation of the different types of liposomal drug delivery systems. (Sercombe L, et al., 2015)

CD Formulation is committed to supporting your projects by leveraging our expert knowledge and state-of-the-art equipment, ensuring a high level of after-sales service. With our liposome drug delivery system platform, we provide optimized solutions tailored to your research needs. Don't hesitate to reach out to us, we're eager to become your trusted partner.

References

Sercombe L, Veerati T, Moheimani F, et al. Advances and challenges of liposome assisted drug delivery. Front. Pharmacol. 2015, 6: 286.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

Related Services