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Nanostructured Lipid Carrier Platforms

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CD Formulation's nanostructured lipid carrier platform represents the advancement of second-generation lipid nanoparticle technology. Unlike solid lipid nanoparticles (SLN), this system boasts enhanced features. By combining solid and liquid lipids, the matrix disrupts the crystalline order of solids, allowing for greater loading of active substances and minimizing the chance of precipitation during storage. This design improves both stability and effectiveness.

Why Choose Nanostructured Lipid Carrier for Nucleic Acid Drug Delivery?

Fig.1 Applications of nanostructured lipid carriers (NLCs). Fig.1 Applications of NLCs. (CD Formulation)

Improved Stability and Bioavailability

With its solid matrix, NLC can maintain stability at ambient temperatures, safeguarding nucleic acids from degradation and enhancing their availability within the body.

Superior Loading Capacity

The combination of solid and liquid lipids in NLC allows for a higher capacity to load active substances compared to conventional carriers, greatly boosting the encapsulation efficiency for nucleic acid therapies.

Tailored Release Profiles

NLCs can be engineered to achieve specific release patterns, optimizing the retention of nucleic acid activity and regulating their release timing.

Outstanding Biocompatibility

Composed of biologically friendly materials, NLCs minimize immune responses, making them ideal for a variety of medical applications.

Technologies for Preparing Nanostructured Lipid Carriers

Items	Descriptions
High-Pressure Homogenization (HPH) Method	Utilizing powerful shear forces, this method transforms lipids into micro-scale particles. It adapts to a range of temperatures and accommodates various drug concentrations.
Solvent Emulsification-Evaporation Method	In this process, lipids and active compounds dissolve in an organic solvent to form an emulsion. The solvent is then gently evaporated under low pressure to create NLCs.
Microemulsion Method	By combining lipids with surfactants, this method produces droplet emulsions that convert into NLC dispersions upon cooling, appreciated for its simplicity and effectiveness.
Solvent Injection Method	This technique involves a quick mixing of lipids with surfactants in a water-based solvent, leading to fast and efficient nanoparticle precipitation.

Capabilities of the Nanostructured Lipid Carrier Platform

CD Formulation's NLC system is crafted for effective nucleic acid drug transport. It adeptly handles diverse nucleic acid types like siRNA, antisense oligonucleotides, and mRNA, safeguarding these molecules during transit to maintain their functional integrity.

Items	Descriptions
siRNA	The NLC platform can effectively encapsulate siRNA, protecting it from enzymatic degradation and achieving targeted gene silencing.
ASO	Encapsulation with NLC allows ASO to be stably delivered into cells, enhancing its role in gene regulation.
mRNA	NLC can safely carry and release mRNA for specific protein expression, supporting protein replacement or vaccine development.
Ribozymes and Other Nucleases	Loading these tool molecules in NLC allows for stable, accurate delivery to target sites, enabling editing or cleavage functions.

Drug Loading Modes in NLC

Fig.2 Methods for encapsulating drugs in nanostructured lipid carriers. Fig.2 Drug loading methods in NLCs. (CD Formulation)

Homogeneous Matrix Model

Drugs are evenly distributed within the lipid matrix, typically achieved using non-surfactant cold homogenization technology, suitable for sustained-release applications.

Drug-Enriched Shell Model

Drugs are concentrated in the carrier shell region, usually formed during a phase separation process, with rapid initial release.

Drug-Enriched Core Model

Drug molecules mainly reside in the carrier's core region, suitable for prolonged release applications, using diffusion principles for controlled release.

Highlights of the Nanostructured Lipid Carrier (NLC) Platform

By combining solid and liquid lipids, our platform achieves higher active substance load, effectively encapsulating multiple drugs.
Our platform utilizes adjustable material design, allowing adaptability to the specific needs of different drugs, enhancing delivery effectiveness.
Our platform supports encapsulation and delivery of multiple drug combinations, suitable for complex therapeutic schemes.
Our platform is designed with production scalability in mind, supporting smooth transition from lab to commercial scale, thus accelerating drug development processes.

Services Provided by the Lipid Nanoparticle Drug Delivery Platform

CD Formulation offers solutions for complex drug delivery challenges through innovative technology. Our Nanostructured Lipid Carrier platform is specifically designed to meet the delivery needs of nucleic acids and small molecule compounds.

Lipid Nanoparticle Development Services

Our platform focuses on providing lipid nanoparticle development services, covering a comprehensive process from conceptual design to laboratory validation. Our services offer customized plans for clients, including carrier optimization, formulation stability assessment, and process parameter tuning, to ensure optimal performance and efficacy.

Publication Data

Technology: Nanostructured lipid carriers (NLCs) platform for topical skin drug delivery

Journal: Pharmaceutics

IF: 4.9

Published: 2023

Results:

The researchers created nanostructured lipid carriers (NLCs) and enriched PFC® hydrogels (HGs) as dual-pathway delivery systems for the topical application of Q and/or ω3, aimed at enhancing the stability and skin penetration of bioactive compounds. They developed two different NLC formulations with identical lipid content but varying surfactant compositions (NLC1 combining soy lecithin with polyoxyethylene polyamide 407, and NLC2 combining Tween® 80 with dioctyl sodium sulfosuccinate (DOSS)), leading to variations in their physicochemical characteristics, pharmaceutical properties, and overall performance. Although both types of NLCs can effectively carry a high load of Q, the properties of NLC2 make it particularly apt for topical use on the skin by maintaining prolonged colloidal stability. Furthermore, NLC2 demonstrated a more prolonged release of Q, indicating enhanced storage capacity for bioactives and better permeability. The occlusive nature of NLC-enriched HGs also contributed positively to skin penetration.

Fig.3 Diagrammatic illustration of nanostructured lipid carriers (NLCs). Fig.3 Schematic representation of nanostructured lipid carriers (NLCs). (Lúcio M, et al., 2023)

If you wish to further explore how CD Formulation's Nanostructured Lipid Carrier platform can support your research projects, feel free to contact us. Our professional team is always ready to customize solutions tailored to meet your specific needs.

References

Lúcio M, Giannino N, Barreira S, et al. Nanostructured lipid carriers enriched hydrogels for skin topical administration of quercetin and omega-3 fatty acid. Pharmaceutics. 2023, 15(8): 2078.

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