CD Formulation's Lipopolyplexes (LPP) Drug Delivery System Platform innovatively delivers nucleic acids by utilizing a unique structural composition that combines the dual benefits of polymers and liposomes, ensuring efficient delivery, stability, and gradual release capabilities.

Advantages of LPP Drug Delivery Systems

LPP stands out with significant advantages over traditional delivery systems. Its dual-layer structure provides robust protection for nucleic acids, particularly mRNA, preventing degradation during delivery and enhancing stability. Additionally, LPP shows remarkable improvements in gene transfection efficiency by enhancing cell membrane interaction through strategically designed cationic lipids and aggregates. The platform's ability to enable gradual release of nucleic acids ensures sustained action within the body, offering prolonged biological effects. Finally, LPP's low-toxicity design minimizes adverse impacts on normal cells, ensuring safety throughout its application.

Fig.1 The formation of Lipopolyplex. (CD Formulation)

Capabilities of the LPP Drug Delivery Platforms

CD Formulation's LPP platform is not confined to delivering only mRNA; its versatility extends to efficiently delivering other nucleic forms, such as plasmid DNA, siRNA, shRNA, and DNA vaccines.

Plasmid DNA Delivery

LPP forms stable complexes with plasmid DNA using cationic polymers, allowing them to penetrate biological membrane barriers. Efficient intracellular transport coupled with a slow-release mechanism ensures sustained expression in target cells.

siRNA Delivery

LPP is engineered to protect siRNA molecules from degradation by intracellular nucleases. During cell delivery, LPP facilitates rapid entry into target cells via cellular uptake, ensuring siRNA reaches the cytoplasm for effective gene silencing.

shRNA Delivery

For shRNA, LPP provides comprehensive protection against degradation before cell entry. Utilizing cellular uptake mechanisms, LPP delivers shRNA to the nucleus where it is transcribed into siRNA, activating precise gene modulation.

DNA Vaccine Delivery

In DNA vaccine delivery, LPP facilitates immune recognition and response to antigens. Its targeted dendritic cell affinity enhances antigen presentation, thereby strengthening immune responses.

Our Solutions of LPP Drug Delivery Platform

CD Formulation's LPP platform provides a variety of innovative solutions for nucleic acid delivery, integrating diverse lipid and polycationic components to allow bespoke designs tailored to specific delivery needs. Our multifunctionality supports various nucleic acid types, greatly expanding application scenarios.

Highlights of the LPP Drug Delivery Platform

• Innovative Dual-layer Design - Our platform features a unique polymer core with a phospholipid shell, ensuring optimal stability and delivery functionality.
• Multifunctional Nucleic Acid Compatibility - Our platform supports delivery of various nucleic forms, including mRNA, plasmid DNA, siRNA, enhancing applicability.
• Precision Cellular Targeting - LPP's structural features allow precise targeting to specific cell types, ensuring delivery accuracy.
• Adjustable Delivery Parameters - Our platform provides flexible options for lipid and polymer combinations to meet diverse research and application needs.

Custom Nucleic Acid Formulation Carrier Services

CD Formulation offers a platform dedicated to the development of customized drug carriers tailored to the unique demands of various nucleic acid medications.

Publication Data

CD Formulation's LPP drug delivery system platform, with its unique design and exceptional performance, provides extensive support for scientific and industrial applications, advancing the frontiers of nucleic acid research. For more information on the LPP platform or to discuss collaboration opportunities, please feel free to contact us.