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Analytical and Characterization Services for Nucleic Acid Drugs

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CD Formulation offers a full range of analytical testing services from nucleic acid drugs formulation development to scale-up. By working with our biopharmaceutical services team, we are able to customize the analytical methods and solutions for your nucleic acid drugs to meet your needs, thus helping you accelerate the formulation development process.

About Nucleic Acid Drugs Analysis and Characterization

The analysis and characterization of nucleic acid drugs requires highly sophisticated analytical workflows with a strong focus on regulatory compliance. Nucleic acid drug molecules are susceptible to the formation of various impurities and degradation products that can seriously affect their safety, efficacy and quality. Through different characterization methods, we can accurately confirm the structural features and purity of nucleic acids, detect their chemical modifications, analyze their interactions with other molecules, and accurately quantify nucleic acid samples to provide reliable basic data for subsequent experimental studies and applications.

Fig.1 Nucleic acid drug analysis instrument. Fig.1 Nucleic acid drug analysis equipment. (CD Formulation)

Explore Our Nucleic Acid Drugs Analysis and Characterization Services

CD Formulation offers a comprehensive range of analytical services to support the development and manufacture of nucleic acid drugs. Our state-of-the-art laboratories are equipped with the latest instrumentation and technology to provide various characterization services.

Items	Descriptions
Identification for Nucleic Acid Drugs	By combining LC-MS and CE-MS techniques, we can perform detailed characterization of nucleic acid drug samples, identifying and quantifying nucleic acids to ensure the highest quality and safety of products.
Structural Characterization for Nucleic Acid Drugs	Our senior scientists use advanced techniques such as NMR spectroscopy and MS to thoroughly elucidate the chemical structures and compositions of nucleic acid drugs, including determining base sequences, modifications, and the possible presence of impurities and degradation products.
Physicochemical Characterization for Nucleic Acid Drugs	Our team focuses on evaluating the physicochemical properties of nucleic acid drugs, such as molecular weight, thermal stability, and higher structure. This comprehensive characterization is essential to understanding the behavior and properties of these complex molecules under different conditions.
Impurity Analysis for Nucleic Acid Drugs	In addition to characterizing the nucleic acid drugs themselves, we can quantify trace metal impurities and residual solvents using advanced techniques such as ICP-MS to ensure product safety.
Stability Analysis for Nucleic Acid Drugs	We can conduct forced degradation tests, real-time stability studies, and accelerated stability analysis to comprehensively evaluate the chemical and physical stability of nucleic acid drugs under different conditions to support product safety and expiration dates.
Safety Analysis for Nucleic Acid Drugs	Safety analysis for nucleic acid drugs involves comprehensive testing and control of particulate matter, sterility, bioburden, and bacterial endotoxins to ensure product quality and biosafety.

Our Technologies for Nucleic Acid Drugs Analysis and Characterization

Spectrophotometer Technology Platform

Measurement of nucleic acid (DNA/RNA) concentration.
Evaluate the purity of nucleic acids by the A260/A280 ratio and determine whether there is contamination by proteins and other impurities.

Gel Electrophoresis Technology Platform

Separate DNA/RNA fragments of different sizes.
Detect integrity and fragmentation of nucleic acids.
Confirm the presence of specific gene sequences.

Real-time PCR Technology Platform

Quantify specific DNA or RNA sequences.
Accurately quantify the amount of target nucleic acids by comparing it to a standard curve.
Widely used in gene expression analysis, pathogen detection, etc.

Sequencing Technology Platform

Determine the nucleic acid sequence information of the entire genome or transcriptome.
Used in genomics and transcriptomics research.
DNA microarrays can simultaneously detect the expression levels of thousands of genes.

Mass Spectrometry Technology Platform

Analyze the chemical modification of nucleic acid molecules, such as methylation and phosphorylation.
Applied to epigenetic research.

Nuclear Magnetic Resonance (NMR) Technology Platform

Determine the three-dimensional conformation of nucleic acid molecules.
To study the relationship between nucleic acid conformation and biological function.

Our Workflow for Nucleic Acid Drugs Analysis and Characterization

Fig.2 Nucleic acid analysis process. Fig.2 Flow chart of nucleic acid drugs analysis and characterization. (CD Formulation)

Why Choose Us for Nucleic Acid Drugs Analysis and Characterization?

Utilizes a variety of advanced analytical techniques to comprehensively assess the structure, sequence, and chemical modifications of nucleic acids.
Adopts proven standard analytical methods to ensure the accuracy and reliability of the data generated, providing a reliable basis for product development.
Systematically compares the analytical results of different batches of nucleic acid samples to ensure product consistency in key indicators such as composition and performance.
It can accurately quantify the content of nucleic acid components in the product and detect possible impurities, providing support for product quality control.

CD Formulation has established a one-stop nucleic acid drug analysis and testing service platform oriented to customers' needs, which can provide comprehensive and perfect testing services for the intermediate control of products and the release of final products. Contact us, our professional team will be happy to serve you.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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