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Sequencing Technology Platform

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Within CD Formulation's Nucleic Acid Drug Sequencing Technology Platform, we utilize the latest high-throughput sequencing tools to perform detailed analysis of DNA and RNA sequences. This approach not only unlocks diverse possibilities for scientific research and development, but also ensures that sequencing is both efficient and budget-friendly. Our platform is equipped with cutting-edge technology, guaranteeing that users receive dependable sequencing results at an affordable price.

Advantages of Sequencing Technology

Nucleic acid sequencing technology provides significant benefits in life sciences. It allows for the precise determination of DNA and RNA sequences, offering researchers a comprehensive genetic map which aids in deepening the understanding of intricate gene functions in living organisms. The high-throughput nature of this technology supports large-scale and simultaneous analysis of multiple samples, speeding up the pace of genetics research. Moreover, advancements in this field have streamlined the identification of novel species or uncharted genes, leading to fresh insights in biodiversity studies. As the costs associated with sequencing continue to fall and the technology's accessibility increases, it is becoming a vital component in genetic exploration and biotechnological innovation, encouraging collaboration across various scientific disciplines.

Fig.1 Benefits of nucleic acid sequencing technology. Fig.1 Advantages of nucleic acid sequencing technology. (CD Formulation)

Applications of Sequencing Platforms

Genetic Research in Humans - Utilizing human samples to study genetic structures and explore variations.
Genetic Research in Non-Humans - Conducting biodiversity assessments involving flora and fauna to evaluate genetic diversity.
Single-Cell Genomic Analysis - Examining genetic content at the resolution of individual cells to identify cellular differences.
Genomic Studies in Cancer - Exploring genetic mutations and profiles that characterize various cancer types.
Advancement in Sequencing Technologies - Developing new sequencing technologies, like long-read sequencing, to meet future scientific challenges.

Types of Sequencing Technology Platforms

Items	Principle	Characteristics
tNGS (Targeted Sequencing) Platform	tNGS is a sequencing method that merges ultra-multiplex PCR or targeted capture with high-throughput sequencing. It involves using specific primers or probes to amplify or capture nucleic acids from a sample, sequencing the target fragments obtained, and conducting bioinformatics analysis for sensitive and high-resolution nucleic acid identification.	Strong specificity High sensitivity High resolution Low cost
mNGS (Metagenomic Sequencing) Platform	mNGS involves rapidly determining the nucleic acid sequence in a sample using a second-generation sequencing platform and comparing it with known species' genome sequences. This technique identifies the types and proportions of microorganisms in the sample. A notable feature of mNGS is that it does not require clinical pre-judgment and can unbiasedly detect all microorganisms within a sample.	Wide coverage High accuracy Obtaining resistance mutation information and virulence genes

Nucleic Acid Sequencing Methods

DNA Sequencing Process

DNA sequencing is a complex technology involving several key steps. First, DNA is extracted and purified from an organism. Next, free DNA bases, DNA primers, fluorescently labeled terminator bases, and DNA polymerase are added to a container. Through a series of heating and cooling cycles, a library of small DNA sequences is generated, each ending with a fluorescently labeled terminator base. The newly created DNA chains are then separated by length, with fluorescence signals excited by a laser and captured by a camera. Finally, a computer assembles the collected information into a full-length DNA sequence.

RNA Sequencing Process

RNA sequencing involves a series of specialized steps. Initially, RNA is extracted, followed by the enrichment of mRNA to obtain the necessary template. Subsequently, a sequencing library is constructed and loaded onto sequencing equipment. Lastly, the resulting data is analyzed and interpreted to reveal RNA expression information and its role in gene regulation.

Highlights of the Nucleic Acid Drug Sequencing Technology Platform

The platform is designed to deliver exceptional sequencing quality while keeping costs reasonable.
Whether you're working on a small project or a large, intricate analysis, the platform is equipped to manage varying project sizes effectively.
A dedicated team of skilled professionals is available to provide guidance and support throughout the research journey.
The system ensures fast turnaround times, maintaining precision and accuracy in data processing.

Our Analytical Characterization Services

CD Formulation's sequencing platform enables in-depth analysis of nucleic acid drugs, concentrating on sequence accuracy and structural insights. Our services guarantee precision and stability in nucleic acid formulations, offering vital tools for researchers in biopharmaceuticals.

Sequence Confirmation

Our service ensures the accuracy of nucleic acid drug sequences, verifying the integrity of the targeted sequences.

Secondary Structure Analysis

This service investigates the formation and stability of secondary structures, such as hairpins and loops, within nucleic acid drugs.

Higher Order Structure Analysis

This service explores the complex three-dimensional structures of nucleic acid drugs and their impact on drug efficacy.

Publication Data

Technology: Next Generation Sequencing (NGS) Platforms for Nucleic Acid Sequence Analysis

Journal: Cells

IF: 7.666

Published: 2023

Results:

Targeted sequencing (TS) has become a vital technology in both clinical and research settings, with benefits such as high confidence and precision, reasonable processing times, affordability, minimal data requirements, and significant computational engagement. Due to the absence of universally agreed guidelines for the diverse next-generation sequencing (NGS) platforms and techniques, there's an urgent demand for developing effective strategies for molecular disease diagnostics, especially during health emergencies and global events like the COVID-19 pandemic. This review aims to summarize various TS methods, detail the design parameters of TS assays, describe different TS panels, address their limitations, and highlight the challenges of applying TS in the molecular analysis of human conditions.

Fig.2 Typical process of an NGS experiment. Fig.2 General workflow of a NGS experiment. (Pei X M, et al., 2023)

At CD Formulation, our Nucleic Acid Drug Sequencing Technology Platform offers precise and detailed analysis for nucleic acid drug development. We emphasize sequence accuracy and structural insights, helping researchers progress with confidence. Contact us, and our advanced equipment and expert team are here to support innovative projects.

References

Pei X M, Yeung M H Y, Wong A N N, et al. Targeted sequencing approach and its clinical applications for the molecular diagnosis of human diseases. Cells, 2023, 12(3): 493.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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