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Zinc Acetate
Product Details
Category
Emollient; Emulsion Stabilizer; Gelling Agents; Opacifier; Stabilizing Agents
Grade
Pharmceutical Excipients
Description
Zinc acetate occurs as white crystalline, lustrous plates with a faint acetic odor and an astringent taste.
UNII
FM5526K07A
Chemical Name
Zinc acetate dihydrate ; Zinc acetate anhydrous
Synonyms
Acetic acid, zinc salt; dicarbomethoxy zinc; zinc acetas dihydricus; zinc (II) acetate; zinc diacetate; zinc ethanoate
Administration route
SC ; topical
Dosage Form
SC injections; topical lotions and solutions
Stability and Storage Conditions
Zinc acetate loses water of hydration above 100℃. Zinc acetate should be stored in an airtight container in a cool, dry, place.
Source and Preparation
Zinc acetate is synthesized by reacting zinc oxide with glacial acetic acid, with subsequent crystallization, separation by centrifugation, and drying and milling of the crystals. No organic solvents are used during the synthesis.
Applications
Zinc acetate has been used as an excipient in a variety of pharmaceutical formulations including topical gels, lotions, and solutions, and subcutaneous injections. It has also been investigated for use in an oral controlled-release formulation for water-soluble drugs in combination with sodium alginate and xanthan gum. Therapeutically, zinc acetate has been used in oral capsules for the treatment of Wilson’s disease. Zinc acetate has also been demonstrated to be effective as a spermicide in vaginal contraceptives.
Safety
Zinc acetate is used in topical pharmaceutical formulations and subcutaneous injections, where it is generally regarded as relatively nontoxic and nonirritant when used as an excipient. However, zinc acetate is poisonous by intravenous and intraperitoneal routes; it is also moderately toxic following oral consumption. Zinc acetate: LD50 (rat, oral): 2.510 g/kg LD50 (mouse, IP): 0.057 g/kg Zinc acetate dihydrate: LD50 (mouse, IP): 0.108 g/kg LD50 (mouse, oral): 0.287 g/kg LD50 (rat, IP): 0.162 g/kg LD50 (rat, oral): 0.794 g/kg
Incompatibilities
Zinc acetate is incompatible with oxidizing agents, zinc salts, alkalis and their carbonates, oxalates, phosphates, and sulfides.
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