API Physical Modification Services

At present, many drugs are often lower than the concentration required for treatment due to their low solubility, even in saturated solutions. In the pharmaceutical liquid preparation industry, it is necessary to increase the solubility of certain drugs. There are many ways to increase the solubility of drugs, and each has its own advantages. Among them, physical treatment is a very common way. CD Formulation enhances the bioavailability and solubility of drugs through API physical modification services, including nanomilling, micronization, co-crystals, amorphous solutions and dispersions and other technical services.

Fig.1 Illustration of drug micronization

Our Services

Bioavailability of active pharmaceutical ingredients (APIs) is a key factor in successful drug development. By choosing API physical modification services, we can support your solution, improve poor water solubility, and control optimized release characteristics to help increase your productivity and return on investment.

• Nanomilling to Prepare Small Particle Size Drug Particles Services
• Micronization Technical Services
• Forming Co-crystals Services
• Amorphous Solutions and Dispersions Technical Services
• Liquid-Solid Compression Services

With leading experts in pharmaceutical formulation development and dosage form optimization, CD Formulation provides you with a one-stop shop for bioavailability and solubility of drugs based on API characteristics and customer development objectives. If you have poorly soluble or insoluble drugs, please contact our staff and we will determine the most appropriate way to assist in your drug development.

If you have a requirement about our services, please contact us by phone or email, our colleagues will reply to you within three working days.

References

1. Christer, B.; et al. Building co-crystals with molecular sense and supramolecular sensibility. Cryst Eng Comm, 2005, 7(72): 439-448.
2. Nakamichi, K.; et al. The role of the kneading paddle and the effects of screw revolution speed and water content on the preparation of solid dispersions using a twin-screw extruder. Int J Pharm, 2002, 241(2):203-211.