Cat.No.	Product Name	CAS	Inquiry
PE-0426	Anhydrous Citric Acid	77-92-9	Inquiry
PE-0015	Citric Acid	5949-29-1	Inquiry
PE-0005	D(-)-Fructose	57-48-7	Inquiry
PE-0008	D-(+)-XYLOSE	41247-05-6	Inquiry
PE-0001	Dibasic Potassium Phosphate Trihydrate		Inquiry
PE-0420	Fructose	57-48-7	Inquiry
PE-0421	Glycine	56-40-6	Inquiry
PE-0004	Saccharin sodium	128-44-9	Inquiry
PE-0124	Sodium Citrate	6132-04-03	Inquiry
PE-0011	Tannic Acid	1401-55-4	Inquiry

Corrective excipients refer to pharmaceutical excipients used in medicines to improve or shield the bitter taste of the drug, making it difficult for patients to perceive the strong bitter taste of the drug (or other peculiar smells such as pungent, irritating, etc.). The substances added to the medicament to conceal and correct the bad smell of the medicament are called flavor correction and odor correction agent. Taste organs are the taste buds on the tongue, and olfactory organs are the olfactory cells in the nasal cavity. Flavor correction and odor correction are closely related to human taste and smell.

Classification

For bitter drugs, the sensitivity of taste buds to the taste of "bitter" can be changed by adding correctives. Sweeteners, fragrances, paralytics and effervescents are all commonly used correctives. In order to interfere with the nerve center's integration of taste signals, so as to cover up the bitter taste.

Sweetener

Sweeteners can mask the salty, astringent, and bitter tastes of drugs. Sweeteners include two major categories: natural and synthetic.

Among the natural sweeteners, sucrose, simple syrup and aromatic syrup are widely used. Aromatic syrups such as orange peel syrup, citric syrup, cherry syrup, licorice syrup and cinnamon syrup can not only correct the taste, but also have the effect of correcting smell. The natural sweetener, stevioside, is a yellowish white powder, odorless, and has a cool and sweet taste. Its sweetness is about 300 times that of sucrose, the sweetness is long-lasting and is not absorbed, and it is a non-calorie sweetener. The heating is stable when the pH value is 4-10. Slightly bitter, so it is often used in combination with sucrose or sodium saccharin. The usual amount is 0.025%~0.05%.

The synthetic sweetener, sodium saccharin, has a sweetness of 200 to 700 times that of sucrose. It is easily soluble in water. The usual amount is 0.03%. It is often used in combination with other sweeteners. Aspartame is also known as protein sugar, and its chemical name is aspartame. It is a dipeptide sweetener with a sweetness of 150 to 200 times that of sucrose, and it has a refreshing sensation. It can be used in low-sugar, low-calorie health foods and medicines.

Fig. 1 The Picture of Sweetener

Fragrance

The spices and essences used in medicines to improve the smell of medicines are called fragrances. Spices are divided into natural flavors and artificial flavors due to their different sources.

Natural flavors include aromatic volatile substances extracted from plants, such as lemon, fennel, peppermint oil, etc., as well as aromatic liquids, tinctures, and spirits made from such volatile substances.

Artificial flavors, also known as flavors, are made by adding appropriate amount of solvents to artificial flavors, such as apple flavor, orange flavor, and banana flavor.

Fig. 2 The Picture of Fragrance

Glue

The mucilage has a viscous and gentle nature, which can interfere with the taste of taste buds and have a taste-correcting effect. Commonly used are sodium alginate, gum arabic, gelatin, methyl cellulose, sodium carboxymethyl cellulose and other mucilages. Sweeteners are often added to the glue to increase its corrective effect.

Effervescent

Effervescent use organic acids (such as citric acid and tartaric acid) to mix with sodium bicarbonate, and produce a large amount of carbon dioxide when it meets with water. Because carbon dioxide is acidic when dissolved in water, it can paralyze the taste buds and improve the taste.

CD Formulation is a leading manufacturer of excipients, serving the pharmaceutical industry to help it improve the performance of its products. If you have any requirements for excipients, please contact us by phone or email, and our colleagues will reply to you within 2-4 working days.