Single-Layer Drug-In-Adhesive Transdermal Patch Development

A single-layer drug-in-adhesive transdermal patch integrates the drug and adhesive into one layer, providing an efficient, user-friendly method to deliver drugs systemically through the skin. With over two decades of formulation expertise, CD Formulation specializes in single-layer drug-in-adhesive transdermal patch development, ensuring optimized drug delivery and performance.

About Single-Layer Drug-In-Adhesive Transdermal Patches

Fig.1 Single-layer drug in adhesive. (Disha A Deulkar, et al. 2024)

Typically, a transdermal patch can be composed of single or multiple layers of solid or semi-solid structures. The configuration of these layers determines the diffusion of the active ingredient through the skin. A single-layer drug-in-adhesive transdermal patch refers to a system where the adhesive layer itself contains the drug. This layer ensures that the patch adheres to the skin while facilitating the controlled release of the drug into the bloodstream through the epidermis and dermis. The backing layer protects the adhesive side prior to application, ensuring the drug is securely contained.

Advantages of Single-Layer Drug-In-Adhesive Transdermal Patches

These patches offer controlled drug release, reducing potential side effects and enhancing patient compliance. Their ability to bypass the liver reduces systemic exposure and improves safety.

Fig.2 Advantages of single-Layer drug-In-adhesive transdermal patches. (CD Formulation)

Our Transdermal Patch Development Services

We offer a full range of transdermal patch development services, ensuring precision and effectiveness in each step:

Optimization of Drug Properties

We can modify the drug as needed, such as nano, to improve its solubility and permeability, thereby enhancing the efficacy of the drug and reducing side effects.

Adhesive Matrix Design

Design the adhesive matrix to control the release of the drug through diffusion or dissolution mechanisms.

Adhesive Formulation

Design the adhesive layer to provide sufficient adhesion to the skin while allowing controlled release of the drug.

Polymer Selection

Selection of suitable polymers for the adhesive matrix that provides good adhesion to the skin and controls the release of the drug at the desired rate.

Workflow for Single-Layer Drug-In-Adhesive Transdermal Patch Development

1. Initial Consultation: We assess your project requirements and propose a tailored development strategy.
2. Formulation Design: Our team designs the transdermal patch matrix and selects the appropriate drug delivery technology.
3. Prototyping: We create prototypes for evaluation and testing.
4. Characterization & Optimization: Using our advanced platform, we optimize the formulation for drug release, stability, and skin adhesion.
5. Scale-Up & Manufacturing: Upon successful prototype validation, we scale up the manufacturing process while maintaining quality and consistency.

Cutting-Edge Technology for Transdermal Systems

• Microparticle and Nanoparticle Technology: We incorporate micro or nanoparticles of the drug into the adhesive matrix to achieve extended or controlled release profiles.
• Advanced Coating Technologies: We apply coating methods such as solvent casting, hot melt coating, or extrusion for accurate adhesive formulations.
• Enhancement of Transdermal Absorption: We leverage physical methods, including electroporation, iontophoresis, and ultrasonic tophoresis, to increase skin permeability and enhance drug absorption.

Our Characterization Platform

Why Choose CD Formulation?

• Our research and development team has deep expertise and rich research and development experience in pharmaceutical preparations, transdermal absorption technology, materials science, and other fields.
• We are committed to the technological innovation of single-layer drug patches, and through continuous research and development and optimization, improve the transdermal efficiency, drug release speed, and bioavailability of patches to ensure the efficacy and safety of products.
• We tailor formulations for various drugs and therapeutic applications, ensuring superior product performance.

Published Data

The single-layer drug-in-adhesive patch is absorbed directly through the skin surface, reducing the side effects of drugs on the liver and other organs, and improving the safety of use. During the product development process, we conducted comprehensive toxicological studies and safety assessments to ensure that the single-layer transdermal patch was safe. At the same time, the effectiveness and safety of the product were verified through clinical trials. If you have any needs, please feel free to contact us, and our colleagues will contact you within three working days.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.