Controlled Release Transdermal Patch Development

Controlled-release transdermal patches represent a sophisticated method for delivering therapeutic compounds through the skin, directly into the bloodstream. At CD Formulation, we specialize in formulation design, optimization, and regulatory compliance, ensuring precision in drug release kinetics. We provide custom development of controlled release transdermal patches tailored to researchers' requirements.

About Controlled Release Transdermal Patches

Controlled-release transdermal patches utilize advanced program-controlled transdermal therapeutic systems. The five-layer structure consists of a backing layer, drug reservoir layer, controlled-release layer, contact adhesive layer, and anti-adhesive protective layer. Once applied, a concentration gradient forms between the drug-saturated polymer reservoir and the skin, promoting a consistent drug release rate. Our innovative microporous filter membrane technology precisely controls the release rate, enabling effective drug delivery through subcutaneous capillaries.

Key Advantages of Controlled Release Transdermal Patches

Controlled release transdermal patches offer numerous advantages over traditional delivery methods, including:

• Stable drug concentration levels
• Reduced gastrointestinal side effects
• Bypassing first-pass liver metabolism
• Non-invasive application, enhancing compliance in research settings

Fig.1 The advantages of controlled release transdermal patches. (CD Formulation)

Custom Controlled Release Transdermal Patch Development

At CD Formulation, we offer a range of custom-controlled release transdermal systems, including:

Membrane Permeation-Controlled TTS

In this type of system, the drug reservoir is encapsulated in a shallow compartment molded from a drug-impermeable metallic laminate and a rate-controlling membrane which may be micro-porous or non-porous. The drug molecules are permitted to be released only through the rate-controlling membrane. In the drug reservoir compartment, the drug solids are either dispersed in a solid polymer matrix or suspended in an unreachable, viscous liquid medium such as silicone fluid to form a paste-like suspension.

Matrix Diffusion-Controlled TTS

In this approach, the drug reservoir is prepared by homogenously dispersing drug particles in a hydrophilic or lipophilic polymer matrix. Use the swelling and dissolution characteristics of the polymer skeleton to control the release process of the drug.

Microneedle-Based Systems

The microneedle system is based on the integral molding of micron-sized needles on the patch substrate, which expands the range of drug molecules and formulations that can be delivered to the skin by painlessly mechanically destroying the skin barrier. The design of a microneedle system with a controlled drug release pattern is mainly affected by the inherent properties of the matrix material, drug binding affinity, and the in vivo environment.

Fig.2 Strategies to develop polymeric microneedles for controlled drug release. (Bo Zhi Chen, et al. 2023)

Advanced Transdermal Absorption Enhancement Technology

We employ state-of-the-art technologies to enhance transdermal absorption:

• Use permeation enhancers (such as ethanol, propylene glycol, etc.) to increase the contact area between the drug and the skin and promote drug penetration through the skin.
• Use adhesion promoters to improve the adhesion of the patch to the skin and extend the residence time of the patch.
• Use carriers such as nanoparticles, microemulsions, and liposomes to improve the transdermal absorption efficiency of drugs.

Why Choose CD Formulation?

• Extensive Experience: Our team has substantial expertise and numerous successful projects in transdermal drug delivery, ensuring responsive and innovative solutions.
• Dedicated Project Management: Experienced project managers oversee the entire process, from planning to quality assurance, guaranteeing on-time, high-quality project completion.
• Tailored Solutions: We develop custom patches for various therapeutic areas, tailored to specific research needs and designed for effective drug delivery.

Published Data

CD Formulation remains committed to advancing the field of transdermal drug delivery, providing customized solutions for research and development. For inquiries, please contact us, and our team will respond within three business days.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.