Reservoir Transdermal Patch Development

In pharmaceutical advancements, reservoir transdermal patches represent a pioneering approach to delivering medications with precision, efficacy, and patient convenience. These patches utilize a sophisticated reservoir system that ensures the controlled release of active pharmaceutical ingredients (APIs) directly through the skin into the bloodstream, offering a myriad of benefits over traditional dosage forms. CD Formulation can provide professional reservoir transdermal patch development.

Overview of Reservoir Transdermal Patches

Fig.1 Illustrates various types of transdermal delivery patches: (a) Single-layer drug-in-adhesive patch;(b) Multi-layer drug-in adhesive patch; (c) Drug reservoir-in-adhesive patch; (d) Drug matrix-in-adhesive patch. (Naziya Shaikh, et al. 2024)

Reservoir-type transdermal patches refer to a class of patches in which drugs form drug reservoirs with osmotic enhancers, thickeners, or other excipients, seal them between the backing and the control film, and control the drug release rate through the controlled release film. Its structure is mainly composed of the backing layer, drug reservoir, controlled release film, adhesive layer, and anti-adhesive layer. The backing layer has a certain mechanical strength, can resist solvent erosion, and generally uses polyester film, polyethylene film, and polyvinylidene chloride copolymer materials; The drug reservoir is a drug-containing layer, and to facilitate production, thickeners or skeleton materials are generally added to make semi-solid; Controlled release film is more important, mainly used to control the release speed of drugs, the thickness is generally between 25-75 μm, the commonly used materials are porous polypropylene film, ethylene - vinyl acetate copolymer (EVA) controlled release film and polyethylene controlled release film. The main function of the adhesive layer is to ensure that the patch can be in close contact with the skin during use, so that the drug can be effectively transmitted to the skin surface, mainly using polyacrylate pressure-sensitive adhesive; The anti-stick layer is the release film that plays a protective role, which needs to be peeled off before use, mainly using silicified polyester film, fluorinated polyester film or silicified paper.

Advantages of Reservoir Transdermal Patches

Fig.2 Advantages of Reservoir Transdermal Patches (CD Formulation)

Our Reservoir Transdermal Patch Development Services

Formulation Design

• Drug Loading: Determine the appropriate concentration of the API in the reservoir to achieve the desired therapeutic effect while ensuring patch stability and integrity.
• Excipient Selection: Identify excipients such as polymers (e.g., polyvinylpyrrolidone, ethylene vinyl acetate), plasticizers (e.g., glycerol, propylene glycol), and permeation enhancers to optimize drug release and skin permeation.

Patch Design

• Reservoir Configuration: Design the reservoir system within the patch to accommodate the drug formulation. This includes selecting materials for the reservoir layer and the rate-controlling membrane.
• Rate-Control Membrane: Choose a membrane that controls the rate of drug release from the reservoir. Common materials include silicone elastomers, polyurethanes, and ethylene vinyl acetate copolymers.
• Backing and Adhesive Layers: Develop the backing layer for structural support and the adhesive layer to ensure patch adherence to the skin.

Workflow for Reservoir Transdermal Patch Development

1. Client Consultation: Understand the specific needs and objectives.
2. Feasibility Study: Conduct a preliminary analysis to determine the project's viability.
3. Formulation Development: Design and optimize the drug formulation and patch configuration.
4. Prototyping: Create prototypes using advanced technologies like 3D printing.
5. Testing and Validation: Conduct rigorous testing to ensure efficacy and safety.

Our Innovative Technology

• Microneedle Technology: Integration of microneedles into patches to enhance drug delivery efficiency and overcome skin barrier resistance.
• Personalized Medicine: We tailored patch formulations to individual patient needs, ensuring optimized therapy based on genetic, metabolic, or physiological factors.
• Advanced Design Techniques: We employ cutting-edge technologies and methodologies in patch design, including CAD software for precise design and 3D printing for prototyping.

Why Choose CD Formulation?

• Advanced Formulation Capabilities: Our team of experienced pharmaceutical scientists specializes in selecting and optimizing drug formulations for optimal transdermal delivery.
• Customized Solutions: We tailor formulations to specific drug characteristics and therapeutic requirements, ensuring precise control over drug release kinetics and efficacy.
• Continuous Optimization: We continuously optimize our processes and methodologies based on scientific advancements and feedback, striving for continuous improvement in patch performance and patient outcomes.

Published Data

At CD Formulation, we excel in reservoir transdermal patch development, leveraging our expertise and state-of-the-art facilities to deliver innovative solutions tailored to meet the diverse needs of our partners and clients. If you have any needs, please do not hesitate to contact us, and our colleagues will contact you within three working days.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.