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Solubilization Technologies for Transdermal Formulation

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Solubilization technology enhances the solubility and absorption of active ingredients in transdermal formulations. It employs specific techniques to optimize the formulation's overall efficacy, helping active ingredients effectively penetrate the skin barrier. CD Formulation integrates advanced nanotechnology with cyclodextrin inclusion technology to enable efficient solubilization and controlled release of active ingredients. By fine-tuning particle size, interfacial tension, and drug release mechanisms, we offer cutting-edge R&D services to pharmaceutical companies and researchers, supporting the development of effective transdermal formulations.

Fig.1 Solubilization technologies for transdermal formulations. Fig.1 Summary of solubilization technologies. (Delly Ramadon, et al. 2021)

Our Highlight - Lipid Nanoparticles Based on Phospholipids

By using the self-assembly property of phospholipids, we can form hollow spherules with bilayer structure. This allows for efficient loading of drugs.

Fig.2 Lipid nanoparticle structure. Fig.2 Schematic diagram of the structure of lipid nanoparticles. (CD Formulation)

Advantages of lipid nanoparticles

It has good permeability of cell membrane.
Excellent safety, no toxicity.
Natural phospholipids have low phase transition temperature, high viscosity at room temperature and strong surface adhesion.
APIs that can be physically embedded or chemically bonded for different structural characteristics.

Application of lipid nanoparticles

High adhesion properties
High permeability
High safety of auxiliary materials
It has a certain slow-release effect

Our Technology Platform for Solubilizing Transdermal Delivery

Nanotechnology

Technology	Specific Information
Nanoemulsions/microemulsions	We take advantage of the small particle size and low interfacial tension of nanoemulsions or microemulsions to enhance the solubilization and penetration of active ingredients on the skin surface. These emulsion systems can lower the interface resistance between drugs and skin.
Nanocarriers	Such as liposomes, nanovesicles, solid lipid nanoparticles, etc. These nanocarriers can wrap active ingredients to form stable nanoparticles. These particles can protect the active ingredient from the outside environment while improving its stability and permeability in the skin.

Cyclodextrin inclusion technology: The cavity of cyclodextrins encapsulates the active ingredient, forming a clathrate. This clathrate boosts the solubility and stability of the ingredient. It also alters its distribution in the skin, enhancing transdermal absorption.
Microneedle technology: Soluble microneedles can overcome the cuticle barrier and achieve painless and autonomous drug delivery. The active substance is freeze-dried into tiny microcrystals. These microcrystals are attached to the patch surface. When applied, they penetrate the skin's stratum corneum. Under the epidermis, they release the active substance.

Transdermal Formulations We Can Develop

Relying on our solubilization technology platform, we can develop a wide range of transdermal formulations for you, include but are not limited to the following:

Gel Transdermal Formulation Development

Gel transdermal systems efficiently administer drugs through skin and membranes using eco-friendly, non-toxic excipients to form viscous liquids or semi-solids.

Cream Transdermal Formulation Development

Creams are versatile semi-solids that emulsify drugs, with variable oil content and texture, allowing diverse formulation options akin to gels.

Ointment Transdermal Formulation Development

Ointments are semi-solid, blending ingredients with bases for a soft texture and sustained drug release, forming protective layers at application sites.

Transdermal Patch Development

Transdermal patches with a matrix deliver drugs at a steady rate; advanced methods ensure efficacy in both local and systemic drug delivery.

Nano Transdermal Patch Development

Nano patches feature nanoparticles designed for skin penetration, customizable with materials like lipids or polymers, enhancing drug release and bioavailability.

Transdermal Microneedle Patch Development

Microneedle patches, with their micron-length needles, are used for minimally invasive tissue penetration. They facilitate targeted drug delivery, reducing systemic side effects.

Why Choose CD Formulation?

Our R&D team is professional. They have deep knowledge and rich experience. They can grasp the latest trends in transdermal solution technology.
We have complete facilities. These include comprehensive laboratories and production lines. They meet the needs of different sizes and complexities.
We have innovative technology in transdermal solubilization. This includes nanotechnology, cyclodextrin inclusion, and microemulsion technology. These technologies improve the solubility, stability, and absorption of active ingredients.
We offer customized services. We can provide solubilization solutions for transdermal formulations. We support customers in selecting active ingredients, optimizing formulations, and adjusting production processes.

Publication Data

Technology: Solubilization Technology

Journal: Drug Delivery and Translational Research

IF: 5.7

Published: 2021

Results: Transdermal drug delivery systems have become an intriguing research topic in the pharmaceutical technology area and one of the most frequently developed pharmaceutical products in the global market. The use of these systems can overcome associated drawbacks of other delivery routes, such as oral and parenteral. The authors will review current trends, and future applications of transdermal technologies, to provide a comprehensive understanding of transdermal drug delivery systems and enhancement strategies. This article will initially discuss each transdermal enhancement method used by first-generation transdermal products. These methods include drug/vehicle interactions, particles, stratum corneum modification, energy-driven methods, and stratum corneum bypassing techniques. Through suitable design and implementation of active stratum corneum bypassing methods, notably microneedle technology, transdermal delivery systems have been shown to deliver both low and high-molecular-weight drugs. Microneedle technology platforms have proven to be more versatile than other transdermal systems with opportunities for intradermal delivery of drugs/biotherapeutics and therapeutic drug monitoring. These have shown that microneedles have been a prospective strategy for improving transdermal delivery systems.

Solubilization is a crucial factor in improving the efficacy of transdermal formulations. At CD Formulation, we utilize micro-emulsion technology, nano-carrier systems, cyclodextrin inclusion, and penetration enhancers to boost transdermal absorption. These technologies work together to maximize the delivery and efficacy of active ingredients. For more information, please contact us. Our team will respond within three business days.

References

Delly Ramadon, Maeliosa T. C. McCrudden, et al. Enhancement strategies for transdermal drug delivery systems: current trends and applications. Drug Delivery and Translational Research. 2022. 12:758–791.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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