Sorbitan Trioleate(span 85)

Product Name

Cat.No.

PE0397

Particle Size

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Price

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Product Details

Category

Surfactants; Emulsifiers; Lubricants; Humectants; Dispersants; Thickeners

Molecular Formula

C60H108O8

Molecular Weight

957.49

Grade

Pharmceutical Excipients

Description

This product is an amber viscous liquid.

UNII

QE6F49RPJ1

Chemical Name

(Z,Z,Z)-Sorbitan tri-9-octadecenoate

CAS Number

26266-58-0

Synonyms

Ablunol S-85; Arlacel 85; Crill 45; Glycomul TO; Hodag STO; Liposorb TO; Montane 85; Nissan Nonion OP-85R; Protachem STO; Prote- sorb STO; S-Maz 85K; Sorbester P37; sorbitani trioleas; Span 85; Tego STO

Administration route

Inhalation; Nasal Administration; Oral; Topical

Dosage Form

Oral inhalation, topical formulation

Stability and Storage Conditions

Gradually saponified under strong acid or strong base; stable in weak acid or weak base. It should be packed in an airtight container and stored in a cool and dry place.

Source and Preparation

This product is a mixture of sorbitol mono-dehydrate, di-dehydrate and three molecules of oleic acid. Its production method is to firstly dehydrate sorbitol at 150-152°C, and esterify it with three molecules of oleic acid under the catalysis of sodium bicarbonate. Or it can be prepared by direct esterification of α-sorbitol and three molecules of oleic acid at 180-280°C.

Applications

This product is used as surfactant, emulsifier, lubricant, wetting agent, dispersant, thickener, defoamer, etc.

Safety

Sorbitan ester is widely used in cosmetics, food, oral and topical pharmaceutical preparations, and is generally considered non-toxic and non-irritating. However, there have been occasional reports of allergic reactions to topical agents containing sorbitan cilexetil. Sorbitan ester emits irritating fumes when heated to decomposition temperature.

Incompatibilities

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