Sorbitan oleate(Span 80)

Product Name

Cat.No.

PE-0627

Particle Size

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Price

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Product Details

Category

Surfactant

Molecular Formula

C24H44O6

Molecular Weight

429

Grade

Pharmceutical Excipients

UNII

06XEA2VD56

Chemical Name

(Z)-Sorbitan mono-9-octadecenoate

CAS Number

1338-43-8

Administration route

Oral administration, local administration, rectal administration

Dosage Form

Inhalants, intramuscular injections, ophthalmic, oral, topical and vaginal preparations

Stability and Storage Conditions

Gradually saponification under strong acid or base conditions; Stable in a weak acid or base. Sorbitan ester should be packed in an airtight container and stored in a cool and dry place.

Source and Preparation

Sorbitol is dehydrated to form 1, 4-sorbitan, which is then esterified with oleic acid.

Applications

Sorbitan ester, as a lipophilic nonionic surfactant, is widely used in cosmetics, food and pharmaceuticals. They are used primarily as emulsifiers in the preparation of creams, emulsions and ointments for topical applications. When used alone, sorbitan ester can produce stable water-in-oil emulsions and microemulsions, but when combined with polysorbitan ester in different proportions, various water-in-oil or oil-in-water emulsions or creams can be prepared.

Safety

Sorbitan ester is widely used in cosmetics, food, oral and local pharmaceutical preparations, generally considered non-toxic, non-irritating. However, there have been occasional reports of allergic skin reactions to topical agents containing sorbitan ester. When heated to decomposition temperature, sorbitan ester releases irritating smoke. WHO determined the daily intake of 25mg per kg of body weight (in terms of total sorbitan) for individuals with single palmetto sorbitan, single stearic sorbitan, tristearic sorbitan, single lauric sorbitan and single oil sorbitan.

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