Powdered Cellulose

Product Name

Powdered Cellulose

Cat.No.

PE0367

Particle Size

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Product Details

Category

Adsorbents; Glidants; Suspending Agentss; Diluents; Disintegrating Agentss

Molecular Formula

(C6H10O5)n, n≈500

Molecular Weight

≈243 000 Since cellulose is extracted from natural polymers, the chain lengths can vary, as can the molecular weight.

Grade

Pharmceutical Excipients

Description

Powdered cellulose occurs as a white or almost white, odorless and tasteless powder of various particle sizes, ranging from a freeflowing fine or granular dense powder, to a coarse, fluffy, nonflowing material.

UNII

SMD1X3XO9M

Chemical Name

Cellulose

CAS Number

9004-34-6

Synonyms

Cellulose, Powdered; Alpha-cellulose; Arbocel; cellulosi pulvis; E460; Elcema; KC Flock; Microcel 3E-150; Sanacel; Sanacel Pharma; Sancel-W; Solka-Floc

Administration route

Oral; Dental; Sublingual; Oral; Topical

Dosage Form

Toothpaste, tablets (including sustained and controlled release preparations, etc.), capsules, drops, dry suspensions, etc.

Stability and Storage Conditions

Powdered cellulose is a stable, slightly hygroscopic substance; it should be kept in an airtight container in a cool, dry place.

Commonly used amount and the maximum amount

Capsule filler: 0~100%; tablet binder: 5%~25%; tablet disintegrant: 5%~15%; tablet glidant: 1%~2%.

Source and Preparation

The α-cellulose slurry obtained from fibrous plants is purified and mechanically reduced to obtain powdery cellulose.

Safety

Powdered cellulose is widely used in oral pharmaceutical preparations and food, and is a non-toxic and non-irritating substance. However, allergic reactions may occur when inhaled, ingested, or in contact with the skin. Powdered cellulose is not absorbed after oral administration and therefore has little toxicity. Cellulose used as a formulation excipient does not cause diarrhea, however, consumption of large amounts of cellulose may act as a laxative. Abuse of preparations containing cellulose by inhalation or injection can lead to the formation of fibrous granulomas. LD50 (rat, oral): >5 g/kg; LD50 (rat, inhalation): 5.8 g/m³/4 h; LD50 (rabbit, dermal): >2 g/kg

Incompatibilities

Incompatibility with strong oxidizing agents.

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