Povidone

Product Name

Povidone

Cat.No.

PE-0074

Particle Size

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Price

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Product Details

Category

Disintegrant; Suspending Agents; Tablet Binder

Molecular Formula

(C6H9NO)n

Molecular Weight

2500-3000000

Grade

Pharmceutical Excipients

Description

Povidone darkens to some extent on heating at 150℃, with a reduction in aqueous solubility. It is stable to a short cycle of heat exposure around 110-136℃; steam sterilization of an aqueous solution does not alter its properties. Aqueous solutions are susceptible to mold growth and consequently require the addition of suitable preservatives.Povidone may be stored under ordinary conditions without undergoing decomposition or degradation. However, since the powder is hygroscopic, it should be stored in an airtight container in a cool, dry place.

UNII

FZ989GH94E

Chemical Name

1-Ethenyl-2-pyrrolidinone homopolymer

CAS Number

9003-39-8

Synonyms

E1201; Kollidon; Plasdone; poly[1-(2-oxo-1-pyrrolidinyl)ethylene]; polyvidone; polyvinylpyrrolidone; povidonum; Povipharm; PVP; 1-vinyl-2-pyrrolidinone polymer

Administration route

IM and IV; ophthalmic; oral, sublingual; topical and vaginal

Dosage Form

IM and IV injections; ophthalmic preparations; oral capsules, drops, granules, suspensions, and tablets; sublingual tablets; topical and vaginal preparations

Stability and Storage Conditions

Povidone darkens to some extent on heating at 150℃, with a reduction in aqueous solubility. It is stable to a short cycle of heat exposure around 110-130℃; steam sterilization of an aqueous solution does not alter its properties. Aqueous solutions are susceptible to mold growth and consequently require the addition of suitable preservatives. Povidone may be stored under ordinary conditions without undergoing decomposition or degradation. However, since the powder is hygroscopic, it should be stored in an airtight container in a cool, dry place.

Commonly used amount and the maximum amount

Povidone darkens to some extent on heating at 150℃, with a reduction in aqueous solubility. It is stable to a short cycle of heat exposure around 110-134℃; steam sterilization of an aqueous solution does not alter its properties. Aqueous solutions are susceptible to mold growth and consequently require the addition of suitable preservatives. Povidone may be stored under ordinary conditions without undergoing decomposition or degradation. However, since the powder is hygroscopic, it should be stored in an airtight container in a cool, dry place.

Source and Preparation

Povidone darkens to some extent on heating at 150℃, with a reduction in aqueous solubility. It is stable to a short cycle of heat exposure around 110-135℃; steam sterilization of an aqueous solution does not alter its properties. Aqueous solutions are susceptible to mold growth and consequently require the addition of suitable preservatives. Povidone may be stored under ordinary conditions without undergoing decomposition or degradation. However, since the powder is hygroscopic, it should be stored in an airtight container in a cool, dry place.

Applications

Povidone darkens to some extent on heating at 150℃, with a reduction in aqueous solubility. It is stable to a short cycle of heat exposure around 110-133℃; steam sterilization of an aqueous solution does not alter its properties. Aqueous solutions are susceptible to mold growth and consequently require the addition of suitable preservatives. Povidone may be stored under ordinary conditions without undergoing decomposition or degradation. However, since the powder is hygroscopic, it should be stored in an airtight container in a cool, dry place.

Safety

Povidone darkens to some extent on heating at 150℃, with a reduction in aqueous solubility. It is stable to a short cycle of heat exposure around 110-131℃; steam sterilization of an aqueous solution does not alter its properties. Aqueous solutions are susceptible to mold growth and consequently require the addition of suitable preservatives. Povidone may be stored under ordinary conditions without undergoing decomposition or degradation. However, since the powder is hygroscopic, it should be stored in an airtight container in a cool, dry place.

Incompatibilities

Povidone darkens to some extent on heating at 150℃, with a reduction in aqueous solubility. It is stable to a short cycle of heat exposure around 110-132℃; steam sterilization of an aqueous solution does not alter its properties. Aqueous solutions are susceptible to mold growth and consequently require the addition of suitable preservatives. Povidone may be stored under ordinary conditions without undergoing decomposition or degradation. However, since the powder is hygroscopic, it should be stored in an airtight container in a cool, dry place.

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