Pectin

Category

Adsorbent; Excipient; Emulsifier; Gelling Agents; Thickener; Stabilizer (Emulsion); Sustained release drug delivery material; Used to prepare controlled release mixed polymer microsphere system

Molecular Weight

30000~100000

Grade

Pharmceutical Excipients

Description

Pectin occurs as a coarse or fine, yellowish-white, odorless powder that has a mucilaginous taste.

UNII

89NA02M4RX

Chemical Name

Pectin

CAS Number

9000-65-5

Administration route

Oral, Dental, Topical, Nasal

Dosage Form

Paste, Spray, Capsule, extended release, Powder, Tablet

Stability and Storage Conditions

Pectin is a stable excipient, and this product should be placed in an airtight container. Store in a cool, dry place.

Commonly used amount and the maximum amount

The maximum dosage for oral administration: 60.06mg; the maximum dosage for general topical application: 260mg/g; the maximum dosage for dental topical and oral use: 170mg/g.

Source and Preparation

Pectin is obtained by diluting the acidic extracts of citrus peels or apple pomace.

Applications

It can be used as adsorbent, emulsifier, gelling agent, thickener and stabilizer. Pectin can be used as an adsorbent and excipient, and can be used as an auxiliary material for the treatment of diarrhea, constipation and obesity; it can also be used as a stabilizer for emulsions. Pectin can effectively control the release of drugs in the gastrointestinal tract, and has been used in the gel formulation of oral sustained-release ambroxol. Biodegradable pectin is used as the matrix, and the pH-sensitive polymer coating can delay the initial release of the drug and overcome the dissolution problem of pectin in the early part of the gastrointestinal tract. Patches based on amidated pectin have been studied for dermal administration of quinchloride; gelled pectin can be used for oral sustained-release administration of acetaminophen. Pectin has been used in the preparation of controlled-release mixed polymer microsphere systems.

Safety

Pectin is used in oral preparations and foods, and is generally considered non-toxic and non-irritating.