Product Details
Category
Emulsifying Agents; Skin Penetrant; Tablet and Capsule Lubricant
Molecular Formula
C16H32O2
Grade
Pharmceutical Excipients
Description
Palmitic acid occurs as white crystalline scales with a slight characteristic odor and taste.
Chemical Name
Hexadecanoic acid
Synonyms
Acidum palmiticum; cetylic acid; Edenor C16 98-100; Emersol 140; Emersol 143; n-hexadecoic acid; hexadecylic acid; Hydrofol; Hystrene 9016; Industrene 4516; Lunac P-95; NAA-160; 1-pentadecanecarboxylic acid
Administration route
Oral
Stability and Storage Conditions
The bulk material should be stored in a well-closed container in a cool, dry, place.
Source and Preparation
Palmitic acid occurs naturally in all animal fats as the glyceride, palmitin, and in palm oil partly as the glyceride and partly uncombined. Palmitic acid is most conveniently obtained from olive oil after removal of oleic acid, or from Japanese beeswax. Synthetically, palmitic acid may be prepared by heating cetyl alcohol with soda lime to 270℃ or by fusing oleic acid with potassium hydrate.
Applications
Palmitic acid is used in oral and topical pharmaceutical formulations. Palmitic acid has been used in implants for sustained release of insulin in rats.
Safety
Palmitic acid is used in oral and topical pharmaceutical formulations and is generally regarded as nontoxic and nonirritant at the levels employed as an excipient. However, palmitic acid is reported to be an eye and skin irritant at high levels and is poisonous by intravenous administration. LD50 (mouse, IV): 57 mg/kg
Incompatibilities
Palmitic acid is incompatible with strong oxidizing agents and bases.