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Nanotechnology for Drug Delivery

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Nanotechnology drug delivery systems have promoted the development of many nanoformulations and greatly promoted the clinical transformation of nanoformulations. With the development of therapeutic drugs, nanotechnology drug delivery strategies need to meet the changing needs of nanoformulation drug delivery. CD Formulation pays close attention to the development and clinical transformation of nanoformulations, tries and explore the research of nanotechnology drug delivery systems, and has constructed a variety of specific nanotechnology platforms to help medical researchers successfully develop nanoformulations with clinical application value.

Advantages of Nanotechnology Drug Delivery Systems

The goal of nanotechnology drug delivery is to passively or actively transport and release nanoformulations to the target site, and to minimize drug off-target effects to maximize the therapeutic effect of the drug. Nanotechnology drug delivery systems can also increase drug solubility, change drug distribution in the body, and improve drug targeting, thereby improving therapeutic effects and reducing the incidence of adverse reactions. Therefore, nanotechnology is widely used in drug delivery systems. The application of nanotechnology in drug delivery systems has the following advantages.

  • Nanotechnology drug delivery systems can improve the ability to deliver poorly water-soluble drugs.
  • Nanotechnology drug delivery systems provide site-specific targeting, which can reduce drug accumulation in healthy tissues.
  • Nanotechnology drug delivery systems can help drugs remain in the body long enough to achieve effective treatment.
  • Nanotechnology drug delivery systems can prolong the biological activity of drugs by protecting the biological environment.
  • Nanotechnology drug delivery systems can allow drugs to cross epithelial and endothelial barriers.
  • Nanotechnology drug delivery systems can be used for both disease treatment and diagnosis.

Our Nanotechnology Drug Delivery Systems

CD Formulation, as a world-class nanoformulation development and manufacturing service company, has accumulated lots of experience in nanotechnology for drug delivery. We can provide customers with nanotechnology for drug delivery services including but not limited to targeting drug delivery system, microparticle drug delivery system, colloidal drug delivery system, self-emulsifying drug delivery system, exosome drug delivery system, in vivo drug delivery strategies based on nanotechnology, co-encapsulation nanomaterial drug delivery system and selective organ targeting particle platform according to customers' different requirements.

Our Nanotechnology-based Drug Delivery Strategies

CD Formulation has advanced instruments and equipment and rich experience in the fabrication of nanoparticles. We can provide a variety of nanoparticle service solutions based on our customers' existing research and development progress.

Nanotechnology-based In Vitro Drug Delivery Strategies

Nanotechnology-based in vitro delivery is a method of delivering exogenous substances such as drugs or genes from outside the cell into the cell under in vitro conditions.

Nanoparticle in vitro delivery system is a technology that uses nanoscale particles as carriers to deliver organic small molecules or biological macromolecules to cells and tissues to be studied. These nanoparticles mainly include lipid-based nanoparticles, polymer nanoparticle carriers (such as polymer micelles, and dendrimers), inorganic nanoparticle carriers (gold nanoparticles, nanospheres, nanorods, nanostars, nanoshells, nanocages, magnetic iron oxide nanoparticles, calcium phosphate and mesoporous silica nanoparticles), etc.

Physically mediated in vitro delivery is a method of using exogenous forces or fields to mediate the entry of exogenous substances to be delivered into cells. Physically mediated in vitro delivery methods we use mainly include microinjection and electroporation delivery.

Nanotechnology-based In Vivo Drug Delivery Strategies

We have developed a series of nanoformulation delivery platforms based on nanotechnology drug delivery systems, which effectively improve the efficiency of drug delivery. Nanotechnology drug delivery systems can be mainly divided into inorganic nanomaterials, polymeric nanomaterials, and lipid nanomaterials. We can reasonably modify and functionalize these delivery systems and select reasonable delivery systems to achieve efficient and accurate nanotechnology-based in vivo drug delivery.

Highlights of Our Nanotechnology Drug Delivery Systems

  • We have constructed multiple nanotechnology platforms such as microparticle technology platform, lipid nanoparticle technology platform, exosome drug delivery system, selective organ targeting particle platform, etc. And we can match customers' different needs for nanotechnology drug delivery system.
  • Relying on our advanced nanotechnology platforms, we can offer multiple nanotechnology drug delivery systems including targeting drug delivery system, microparticle drug delivery system, colloidal drug delivery system, self-emulsifying drug delivery system, exosome drug delivery system, in vivo drug delivery strategies based on nanotechnology, “co-encapsulation” nanomaterials drug delivery system and selective organ targeting particle platform.
  • Our core team has rich experience in the research of nanotechnology-based drug delivery system strategies, especially in vitro and in vivo drug delivery strategies based on nanotechnology.

Custom Nanoformulation Development Services

CD Formulation has always been at the forefront of nanoformulation formulation development. With the support of our advanced nanotechnology platform, we provide customized formulation development services for nanoformulations, covering nanoparticles, nanoemulsions, nanocrystals, nanosuspensions, nanogels, etc. Our technical team has deeply studied nanotechnology and applications and is able to develop nanoformulations for different purposes. We have always been working tirelessly to promote the rapid development of clinical transformation and commercial application of nanoformulations.

Nanoformulation Development

Using our advanced nanotechnology, CD Formulation offers tailored development services for various nanoformulations like nanoparticles, nanoemulsions, and polymeric micelles. Our deep expertise in nanoformulation properties and applications allows us to deliver personalized solutions that enhance bioavailability, stability, and clinical safety.

Published Data

Technology: Nanotechnology-based delivery systems

Journal: Journal of Controlled Release

IF: 10.8

Published: 2023

Results:

The authors summarize the different nanotechnology-based delivery systems used to treat and manage diseases affecting the anterior ocular tissues, such as micelles, nanosuspensions, nanoparticles, nanoemulsions, liposomes, dendrimers, liposomes, cubes, and nanowafers, which have emerged as effective alternatives to conventional ocular delivery systems for the treatment of anterior segment diseases. The authors also examine the challenges in translating these systems into clinical applications and the promise of nanocarriers as vehicles for the delivery of phytoactive compounds to the anterior segment of the eye.

Fig.1 Nanotechnology-based drug delivery systems for ocular.Fig.1 Nanotechnology-based drug delivery systems for ocular application. (Adaeze Linda Onugwu, et al. 2023)

With the rapid development of nanotechnology, nanotechnology drug delivery systems have entered a white-hot research stage. As a service company leading nanotechnology research, CD Formulation has always been at the forefront of the exploration and development of nanotechnology drug delivery systems. We have created multiple nanotechnology platforms to provide full support for the development of nanotechnology drug delivery systems. If you are interested in our nanotechnology drug delivery system services, please feel free to contact us.

References

  1. Adaeze Linda Onugwu, Chinekwu Sherridan Nwagwu, Obinna Sabastine Onugwu, et al. Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases. Journal of Controlled Release. 2023,354,465-488. 
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