As advancements in nanoparticle technology continue, nanoformulations open new frontiers in the treatment of diseases, including cancer, infectious diseases, and neurological disorders. CD Formulation focuses on developing customized nanoformulations to enhance drug targeting, increase therapeutic concentration at lesion sites, and reduce toxicity, ensuring safer and more effective treatments.

Applications of Nanoformulations in Disease Therapies

In recent years, nanoformulations have been widely used in many therapeutic fields, such as cancer therapy, cancer immunotherapy, cardiovascular disease treatment and heart disease treatment, etc.

Targeted Tumor Therapies

Nanoformulations for the treatment of tumor diseases are one of the hottest areas of high-end formulation research. The use of nanoformulations has greatly improved the safety and efficacy of common anti-cancer drugs. The main advantages of nanoformulation and delivery systems based on nanotechnology are effective targeting, delayed release, extended half-life and reduced systemic toxic effects. The use of nanoformulations has significantly improved drug delivery to targets.

Cancer Immunotherapy

Nanoparticles have unique nanoscale properties of the delivery agent, morphology, non-rigid modulation of the delivery agent's magnetic forces, and surface properties that contain target moieties and charges, so their shape can influence the production of antibodies and cytokines. Nanoparticles accumulate primarily within tumors due to their weak lymphatic drainage and vasculature dripping, thereby enhancing permeability and retention responses. Nanomaterials are easily modified, and targeting ligands that have been loaded externally can promote the uptake of nanomaterials by specific cells. Therefore, nanomaterials can inherently modulate immune responses.

Fig.1 Cancer immunotherapy and its multidisciplinary requirements; nanotechnology can help cancer immunotherapy in different aspects. (Forough Shams, et al. 2022)

Cardiovascular Disease Therapies

Nanoparticles can improve the targeting of drugs to overcome biological barriers. New nanocarriers that enter the blood circulation can be selectively taken up by immune cells to modulate the inflammatory process and migrate locally to plaques to deliver therapeutic payloads. We inject designed nanoparticles into the vasculature or target blood vessels to achieve the purpose of treating heart-related diseases such as atherosclerosis, hypertension, and myocardial infarction.

Approved Nanoformulation for Cancer Therapies

With the continuous development and exploration of nanotechnology platforms, many types of nanoformulations have been developed and approved by multiple institutions around the world for the treatment of cancer, including liposomes, metal and metal oxide nanoparticles, polymer micelles and lipid nanoparticles, and other nanoformulations are in different stages of clinical and preclinical trials.

Table 1 Approved nanomedicine drugs in the market for cancer treatment. (M. Joyce Nirmala, et al. 2023)

In recent years, the number of nanoformulations in clinical trials has continued to increase, and many trials are currently in Phase II and Phase III. Liposomes and their mixtures, as well as many metal oxide nanoparticles, carbon quantum dots, polymer micelles, nanoemulsions, and other types of nanoformulations have also entered clinical trial research, which provides certain technical support for the commercialization of nanoformulations.

Table 2 Nanomedicine drugs under clinical trial for cancer treatment. (M. Joyce Nirmala, et al. 2023)

Our Nanoformulation Development for Therapeutic Research

The new drug delivery system we developed using nanotechnology has great potential in loading chemotherapeutic drugs, peptide and protein drugs, gene drugs, etc. CD Formulation has been committed to exploring and researching novel nanodrug delivery materials for various therapeutic research, covering nanoparticles, liposomes and lipid nanoparticles, polymeric nanoparticles, nanocrystals, carbon-coated iron oxide nanoparticles, etc.

Why Choose CD Formulation?

• CD Formulation has constructed multiple nanotechnology platforms to customize high-quality nanoformulations for therapeutic research, including nanoparticles, liposomes and lipid nanoparticles, polymeric nanoparticles, nanocrystals and carbon-coated iron oxide nanoparticles.
• We can provide customers with nanoformulation for therapeutic research based on nanoparticles, liposomes, nanocrystals, polymeric micelles, etc.
• We also have rich experience in exploring clinical applications of nanoformulation in therapeutic research, such as cancer therapy, cancer immunotherapy, and cardiovascular therapeutic research.

Nanoformulations have significant potential in therapeutic research due to their unique properties that can improve the stability of nanoformulations, control their drug release, and increase bioavailability. As a world-leading nanoformulation manufacturing servicing company, CD Formulation can provide customers with nanoformulation development services for therapeutic research, especially in the field of cancer therapy. If you are interested in our nanoformulations for therapeutic research, please contact us to discuss this potential collaboration further.