To deeply research and flexibly modify nanocrystals, CD Formulation has established an unparalleled nanocrystalline technology delivery system. At this system, we have accumulated extensive experience in the fabrication approaches of pharmaceutical nanocrystals. We also provide excellent nanocrystal customization services to accelerate customers' nanoformulation development and therapeutic research.
Due to their benefits of high safety, high bioavailability, improved druggability, and high drug loading, pharmaceutical nanocrystals have widespread applications in treating neurodegenerative diseases, cancer therapy, the management of dermatological diseases, etc.
Nanocrystal technologies have achieved effective brain-targeted brain delivery and improvement of the drug delivery due to their unique benefits, such as increased dissolution rate, saturated solubility, high drug loading, drug absorption, bioavailability, etc.
Fig.1 Applications of nanocrystals in treating neurodegenerative diseases.(Zhi Xin Phuna, et al. 2022)
Nanocrystals offer their significant advantages in topical drug delivery, including higher concentrations of therapeutic drugs at the site of application, scalable production methods, dissolution without excessive pH range and cosolvents, increased apparent solubility, adhesion, and dissolution rate. Our nanocrystal-based formulations have widespread potential in treating skin diseases, such as atopic dermatitis, wound healing, fungal infections, psoriasis, etc.
We precisely control the physical and chemical properties of the metal nanocrystals by modifying the nanocrystal size and shape. We have also constructed our novel and flexible platform for targeted drug therapy, real-time imaging, and monitoring of therapeutic responses by their surface functionalization. Moreover, the pharmaceutical nanocrystals can be rapidly eliminated from the body and are inherently biocompatible. Therefore, our metal nanocrystals can be used to encapsulate or bind drug molecules to precisely deliver therapeutic agents to tumor cells.
We have created a nanocrystal-based intra-articular delivery system by modifying or engineering the nanocrystals, which has appropriate stability and controlled-release properties and is non-toxic in human synovial cells, enabling broad use in the treatment of osteoarthritis.
The pharmaceutical nanocrystals are widely used for therapeutic research due to their significant properties of crystalline or amorphous structure, increasing dissolution velocity, and increasing saturation solubility. With the support of our nanocrystalline technology platform, CD Formulation specifies the development and customization of pharmaceutical nanocrystals for the treatment of various diseases to meet customers' different personalized needs.
Technology: Nanocrystalline chitosan particle delivery system for the treatment of osteoarthritis
Journal: International Journal of Pharmaceutics
IF: 5.3
Published: 2024
Results:
The authors designed a unique nanocrystalline chitosan particle-based intra-articular delivery system for the treatment of osteoarthritis. The authors reduced the drug to nanosize by wet milling and spray drying, and the final drug delivery system consisted of easily resuspended and ready-to-use microsphere powders for intra-articular injection. The chitosan microspheres showed appropriate stability and controlled-release properties in synovial fluid and were non-toxic in human synovial cells. This drug delivery system has great potential in the treatment of osteoarthritis.
Fig.2 Nanocrystal-chitosan particles for intra-articular delivery of disease-modifying osteoarthritis drugs. (Luca Morici, et al. 2024)
Pharmaceutical nanocrystals play an important role in the treatment of different diseases, such as neurodegenerative diseases, cancer therapy, the management of dermatological diseases, etc. CD Formulation, as your most trusted cooperative nanoformulation development service company, can provide customers with our personalized and excellent pharmaceutical nanocrystal customization services for therapeutic research. If you are interested, please contact us for further communication and in-depth discussion.
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