Through our functionalized modification of iron oxide nanoparticles by inorganic materials, carbon-coated iron oxide nanoparticles have widespread applications for disease treatment, especially tumor therapy. CD Formulation has extensive experience in the fabrication of carbon-coated iron oxide nanoparticles for different disease treatments. We can fabricate high-quality carbon-coated iron oxide nanoparticles to promote nanoformulation development and applications.
Iron oxide nanoparticles have controlled size, easy functional modification, and easy drug loading. We have developed carbon-coated iron oxide nanoparticles using our carbon-coating technologies.
Iron oxide nanoparticles have excellent key futures of super magnetism, size controllability, adjustable size and shape, and easy surface modification. We leverage the novel carbon coating techniques to improve the biocompatibility and stability of iron oxide nanoparticles. Therefore, carbon-coated iron oxide nanoparticles have broad application potential in the field of disease treatment.
Fig.1 The biomedical applications of iron oxide nanoparticles. (Yu Qing Meng, et al. 2024)
Iron oxide nanoparticles have amazing applications in cancer diagnosis and MRI on account of generating strong signals in magnetic fields. And carbon coating can further enhance these properties to improve imaging sensitivity and accuracy.
Iron oxide nanoparticles have powerful functions of increasing drug targeting and bioavailability. And carbon coating further enhances this function, making drug delivery systems more efficient and safer.
Carbon-coated iron oxide nanoparticles can not only target the tumor under the guided magnetic field but also protect nanoparticles from recognition by the immune system.
Carbon coating can further improve the biocompatibility and stability of carbon-coated iron oxide nanoparticle technology systems to support diagnosis and atherosclerosis treatment.
CD Formulation explores the strategies for improving the physical and chemical properties of iron oxide nanoparticles by passivating the surface or carbon coating. We also have constructed the inorganic nanoparticle technology platform. At this platform, we are able to offer carbon-coated iron oxide nanoparticle customization and characterization services for disease treatment, catering to customers' personalized requirements and promoting the progress of preclinical research.
Fig.2 The main approaches to the modification of iron oxide nanoparticles. IONPs—iron oxide nanoparticles, mAb—monoclonal antibodies, and HA—hyaluronic acid. (Maria V. Shestovskaya, et al. 2023)
Technology: The surface modification of magnetite nanoparticles as biocompatible and multifunctional nanoplatforms for cancer therapy.
Journal: ACS Applied Materials & Interfaces
IF: 8.3
Published: 2024
Results:
The authors constructed a surface modification of magnetite nanoparticles to obtain a biocompatible and multifunctional nanoplatform with broad potential for application in cancer therapy. The authors also prepared and characterized Fe3O4 nanoparticles coated in situ with dextran and glucosamine-based amorphous carbon coatings with potent reducing activity and tested their effects on drug-induced. The study showed that carbon-coated iron oxide nanoparticles can promote reductive stress-mediated cytotoxicity in non-senescent breast cancer cells and can be considered as stimulators of reductive stress and cytotoxic effects.
Fig.3 Carbon-coated iron oxide NPs (Fe3O4@aC) promote cytotoxic effects in drug-induced senescent breast cancer cells with different gene mutation statuses (left) that are mechanistically achieved by the induction of reductive stress (decreased ROS production, elevated levels of antioxidant proteins such as FOXO3a, SOD1, and GPX4) (right). (Anna Lewińska, et al. 2024)
Carbon-coated iron oxide nanoparticles are versatile biomedical materials with broad application prospects in the field of disease treatment. We have designed and modified iron oxide nanoparticles based on carbon coating to improve their biocompatibility, stability, and therapeutic effects in order to rapidly support the preclinical research. CD Formulation, as your faithful commercial cooperating partner, can develop and customize the personalized carbon-coated iron oxide nanoparticles for therapeutic research. If you are interested in our carbon-coated iron oxide nanoparticle customization services for therapeutic research, please contact us.
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