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Carbon-coated Iron Oxide Nanoparticles for Therapeutic Research

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Through our functionalized modification of iron oxide nanoparticles by inorganic materials, carbon-coated iron oxide nanoparticles have widespread applications for disease treatment, especially tumor therapy. CD Formulation has extensive experience in the fabrication of carbon-coated iron oxide nanoparticles for different disease treatments. We can fabricate high-quality carbon-coated iron oxide nanoparticles to promote nanoformulation development and applications.

Advantages of Carbon-coated Iron Oxide Nanoparticles in Therapeutic Research

Iron oxide nanoparticles have controlled size, easy functional modification, and easy drug loading. We have developed carbon-coated iron oxide nanoparticles using our carbon-coating technologies.

  • Good biocompatibility.
  • Low toxicity.
  • Supermagnetic properties.
  • Deliver drugs and genes to target cells.
  • Antibacterial activity.
  • Detect target cells and treat various cancers.
  • Synergistic therapy for the diagnosis and tumors.

Applications Carbon-coated Iron Oxide Nanoparticles

Iron oxide nanoparticles have excellent key futures of super magnetism, size controllability, adjustable size and shape, and easy surface modification. We leverage the novel carbon coating techniques to improve the biocompatibility and stability of iron oxide nanoparticles. Therefore, carbon-coated iron oxide nanoparticles have broad application potential in the field of disease treatment.

Fig.1 Applications of iron oxide nanoparticles in therapeutic research.Fig.1 The biomedical applications of iron oxide nanoparticles. (Yu Qing Meng, et al. 2024)

Carbon-coated Iron Oxide Nanoparticles in Cancer Diagnosis and MRI

Iron oxide nanoparticles have amazing applications in cancer diagnosis and MRI on account of generating strong signals in magnetic fields. And carbon coating can further enhance these properties to improve imaging sensitivity and accuracy.

Carbon-coated Iron Oxide Nanoparticles in Drug Delivery

Iron oxide nanoparticles have powerful functions of increasing drug targeting and bioavailability. And carbon coating further enhances this function, making drug delivery systems more efficient and safer.

Carbon-coated Iron Oxide Nanoparticles in Cancer Therapy

Carbon-coated iron oxide nanoparticles can not only target the tumor under the guided magnetic field but also protect nanoparticles from recognition by the immune system.

Carbon-coated Iron Oxide Nanoparticles in Atherosclerosis Treatment

Carbon coating can further improve the biocompatibility and stability of carbon-coated iron oxide nanoparticle technology systems to support diagnosis and atherosclerosis treatment.

Custom Carbon-coated Iron Oxide Nanoparticles for Therapeutic Research

CD Formulation explores the strategies for improving the physical and chemical properties of iron oxide nanoparticles by passivating the surface or carbon coating. We also have constructed the inorganic nanoparticle technology platform. At this platform, we are able to offer carbon-coated iron oxide nanoparticle customization and characterization services for disease treatment, catering to customers' personalized requirements and promoting the progress of preclinical research.

Fig.2 The modification methods of iron oxide nanoparticles for therapeutic research.Fig.2 The main approaches to the modification of iron oxide nanoparticles. IONPs—iron oxide nanoparticles, mAb—monoclonal antibodies, and HA—hyaluronic acid. (Maria V. Shestovskaya, et al. 2023)

Why Choose CD Formulation?

  • Upon our nanoparticle technology platform, we customize the high-quality carbon-coated iron oxide nanoparticle for therapeutic research.
  • Through our continuous experiments and exploration, our core technical team pursues excellence in the carbon-coating technologies based on iron oxide nanoparticles.
  • We harbor extensive experience in deeply studying the fabrication techniques of iron oxide nanoparticles based on SiO2, carbon, etc.

Published Data

Technology: The surface modification of magnetite nanoparticles as biocompatible and multifunctional nanoplatforms for cancer therapy.

Journal: ACS Applied Materials & Interfaces

IF: 8.3

Published: 2024

Results:

The authors constructed a surface modification of magnetite nanoparticles to obtain a biocompatible and multifunctional nanoplatform with broad potential for application in cancer therapy. The authors also prepared and characterized Fe3O4 nanoparticles coated in situ with dextran and glucosamine-based amorphous carbon coatings with potent reducing activity and tested their effects on drug-induced. The study showed that carbon-coated iron oxide nanoparticles can promote reductive stress-mediated cytotoxicity in non-senescent breast cancer cells and can be considered as stimulators of reductive stress and cytotoxic effects.

Fig.3 Carbon-coated iron oxide nanoparticles in senescent breast cancer.Fig.3 Carbon-coated iron oxide NPs (Fe3O4@aC) promote cytotoxic effects in drug-induced senescent breast cancer cells with different gene mutation statuses (left) that are mechanistically achieved by the induction of reductive stress (decreased ROS production, elevated levels of antioxidant proteins such as FOXO3a, SOD1, and GPX4) (right). (Anna Lewińska, et al. 2024)

Carbon-coated iron oxide nanoparticles are versatile biomedical materials with broad application prospects in the field of disease treatment. We have designed and modified iron oxide nanoparticles based on carbon coating to improve their biocompatibility, stability, and therapeutic effects in order to rapidly support the preclinical research. CD Formulation, as your faithful commercial cooperating partner, can develop and customize the personalized carbon-coated iron oxide nanoparticles for therapeutic research. If you are interested in our carbon-coated iron oxide nanoparticle customization services for therapeutic research, please contact us.

References

  1. Yu Qing Meng, Ya Nan Shi, Yong Ping Zhu, et al. Recent trends in preparation and biomedical applications of iron oxide nanoparticles. Journal of Nanobiotechnology. 2024,22:24
  2. Maria V. Shestovskaya, Anna L. Luss, Olga A. Bezborodova, et al. Iron Oxide Nanoparticles in Cancer Treatment: Cell Responses and the Potency to Improve Radiosensitivity. Pharmaceutics. 2023,15(10),2406.
  3. Anna Lewińska, Adrian Radoń, Kacper Gil, et al. Carbon-Coated Iron Oxide Nanoparticles Promote Reductive Stress-Mediated Cytotoxic Autophagy in Drug-Induced Senescent Breast Cancer Cells. ACS Applied Materials & Interfaces. 2024,16(12):15457-15478.
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