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Microcrystalline Cellulose PH105
Product Details
Category
Adsorbent; Suspending Agents; Diluent for tablets and capsules; Disintegrant for tablets
Molecular Formula
(C6H10O5)n n n≈220
Molecular Weight
≈36000
Grade
Pharmceutical Excipients
Description
Microcrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. It is commercially available in different particle sizes and moisture grades that have different properties and applications.
UNII
OP1R32D61U
Chemical Name
Cellulose PH105
CAS Number
9004-34-6
Synonyms
Avicel PH 105; Celex PH105; cellulose-gel PH105; Celphere PH105; Ceolus-KG PH105; crystalline-cellulose PH105; E460 PH105; Emcocel PH105; Ethispheres PH105; Fibrocel PH105; Pharmacel PH105; Tabulose PH105; Vivapur PH105
Administration route
Oral; Topical
Dosage Form
Inhalation; Oral Capsule; Granules; Suspension; Syrup; Tablet; Topical and Vaginal
Stability and Storage Conditions
This product is a hygroscopic, but stable substance. Large quantities of storage must be placed in airtight containers in a cool and dry environment.
Source and Preparation
Microcrystalline cellulose can be obtained by controlled hydrolysis of α-cellulose with dilute mineral acid solution, and α-cellulose can be obtained from fiber pulp of cellulose-containing plants. After hydrolysis, the hydrolyzed cellulose is filtered and purified, and the water slurry is spray-dried to form dry porous particles with a wide particle size distribution.
Applications
Adsorbent; suspending agent; diluent for tablets and capsules; disintegrant for tablets. Microcrystalline cellulose PH105.is suitable for wet granulation.
Safety
This product is widely used in oral pharmaceutical preparations and food, and is a relatively non-toxic and non-irritating substance. This product is not absorbed after oral administration and has almost no potential toxicity. A large amount of use may cause mild diarrhea, and it is not difficult to use as a pharmaceutical excipient. Abuse of certain tablets containing cellulose, such as inhalation or injection administration, can lead to fibrous granulomas.
Incompatibilities
This product is incompatible with strong oxidizing agents.
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Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.
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