Product Details
Molecular Formula
C17H25N3O5S•xNa2CO3
Molecular Weight
383.46 (free acid)
Grade
Pharmaceutical grade
Description
Meropenem with sodium carbonate is a salt form of Meropenem, a β-lactam antibiotic of the carbapenem subclass that has been shown to inhibit penicillinase-negative, -positive and methicillin-susceptible staphylococci. This compound demonstrates the ability to also affect strains of 11 species of streptococci. Mechanistic studies suggest that Meropenem′s antimicrobial activity is based on its high affinity for the majority of penicillin-binding proteins, which are cell wall-synthesizing enzymes. Meropenem is very effective because it resists inactivation by the majority of microbial LACTB (β-lactamases) as well as kidney dehydropeptidase I. Experiments have shown Meropenem to have a low toxicity profile and, in contrast to similar compounds, no central nervous system toxicity.
Chemical Name
Meropenem with sodium carbonate
CAS Number
96036-03-2 free acid
Synonyms
(4R,5S,6S)-3-[[(3S,5S)5-[(Dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3,2,0]hept-2-ene-2-carboxyloc acid
Stability and Storage Conditions
Store at 4° C
Applications
Meropenem with sodium carbonate is a salt form of Meropenem, a β-lactam antibiotic of the carbapenem subclass that has been shown to inhibit penicillinase-negative, -positive and methicillin-susceptible staphylococci. This compound demonstrates the ability to also affect strains of 11 species of streptococci. Mechanistic studies suggest that Meropenem′s antimicrobial activity is based on its high affinity for the majority of penicillin-binding proteins, which are cell wall-synthesizing enzymes. Meropenem is very effective because it resists inactivation by the majority of microbial LACTB (β-lactamases) as well as kidney dehydropeptidase I. Experiments have shown Meropenem to have a low toxicity profile and, in contrast to similar compounds, no central nervous system toxicity.
Safety
α20D -19±2, c = 1 in water