Meglumine

Product Name

Meglumine

Cat.No.

PE-0598

Particle Size

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Price

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Product Details

Category

Organic Base: pH regulator; Solubilizing Agents

Molecular Formula

C7H17NO5

Molecular Weight

195.21

Grade

Pharmceutical Excipients

Description

Meglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor.

UNII

6HG8UB2MUY

Chemical Name

1-Deoxy-1-(methylamino)-D-glucitol

CAS Number

6284-40-8

Synonyms

Meglumin; meglumina; megluminum; 1-methylamino-1-deoxy-Dglucitol; N-methylglucamine; N-methyl-D-glucamine

Administration route

Intramuscular injection; Intravenous injection; Oral

Dosage Form

Injection, tablet, capsule

Stability and Storage Conditions

Meglumine does not polymerize or dehydrate unless heated above 150℃ for prolonged periods. The bulk material should be stored in a well-closed container in a cool, dry place. Meglumine should not be stored in aluminum containers since it reacts to evolve hydrogen gas; it discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended.

Source and Preparation

Meglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation.

Applications

Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media.

Safety

Meglumine is widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient. LD50 (mouse, IP): 1.68 g/kg

Incompatibilities

Incompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizid.

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