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Isopropyl Palmitate
Product Details
Category
Carrier Excipients
Molecular Formula
C19H38O2
Molecular Weight
298.51
Grade
Pharmceutical Excipients
Description
Isopropyl palmitate is a clear, colorless to pale yellow-colored, practically odorless viscous liquid that solidifies at less than 16℃.
UNII
8CRQ2TH63M
Chemical Name
1-Methylethyl hexadecanoate
CAS Number
142-91-6
Synonyms
Emerest 2316; hexadecanoic acid isopropyl ester; hexadecanoic acid 1-methylethyl ester; isopropyl hexadecanoate; isopropylis palmitas; Isopropylpalmitat; Kessco IPP; Lexol IPP-NF; Liponate IPP; palmitic acid isopropyl ester; Propal; Protachem IPP; Rita IPP; Stepan IPP; Super Refined Crodamol IPP; Tegosoft P; Unimate IPP; Waglinol 6016; Wickenol 111.
Administration route
Topical and transdermal
Dosage Form
Topical and transdermal preparations
Stability and Storage Conditions
Isopropyl palmitate is resistant to oxidation and hydrolysis, and does not become rancid. It should be stored in a well-closed container, above 16℃, and protected from light.
Source and Preparation
Isopropyl palmitate is prepared by the reaction of palmitic acid with propan-2-ol in the presence of an acid catalyst. A high-purity material is also commercially available, which is produced by enzymatic esterification at low temperatures.
Applications
Isopropyl palmitate is a nongreasy emollient with good spreading characteristics, used in topical pharmaceutical formulations and cosmetics such as: bath oils; creams; lotions; make-up; hair care products; deodorants; lip products; suntan preparations; and pressed powders. Isopropyl palmitate is an established penetration enhancer for transdermal systems. It has also been used in controlled-release percutaneous films.
Safety
Isopropyl palmitate is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a relatively nontoxic and nonirritant material.
LD50 (mouse, IP): 0.1 g/kg
LD50 (mouse, IP): 0.1 g/kg
Incompatibilities
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