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Glycine
Product Details
Category
Buffering Agents; Tablet Dsintegrant; Wetting Agents
Molecular Formula
C2H5NO2
Molecular Weight
75.07
Grade
Pharmceutical Excipients
Description
Glycine occurs as a white, odorless, crystalline powder, and has a sweet taste.
UNII
TE7660XO1C
Chemical Name
Aminoethanoic acid
CAS Number
56-40-6
Synonyms
Aminoacetic acid; 2-aminoacetic acid; E640; G; Gly; glycinum; glycoamin; glycocoll; glycoll; glycolixir; glycinium; Hampshire glycine; padil; sucre de ge´latine
Administration route
IM, IV, SC injections; oral; rectal
Dosage Form
IM, IV, SC injections; oral; rectal; orodispersible tablets/oral lyophilizate; powders for inhalation; powders for oral solution; tablets
Stability and Storage Conditions
Glycine starts to decompose at 233℃. Store in well-closed containers. Glycine irrigation solutions (95-105% glycine) should be stored in single dose containers, preferably type I or type II glass.
Source and Preparation
Chemical synthesis is the most suitable method of preparation of glycine. Amination of chloroacetic acid and the hydrolysis of aminoacetonitrile are the favored methods of production.
Applications
Glycine is routinely used as a cofreeze-dried excipient in protein formulations owing to its ability to form a strong, porous, and elegant cake structure in the final lyophilized product.It is one of the most frequently utilized excipients in freeze-dried injectable formulations owing to its advantageous freeze-drying properties. Glycine has been investigated as a disintegration accelerant in fast-disintegrating formulations owing to its excellent wetting nature.It is also used as a buffering agent and conditioner in cosmetics. Glycine may be used along with antacids in the treatment of gastric hyperacidity, and it may also be included in aspirin preparations to aid the reduction of gastric irritation.
Safety
Glycine is used as a sweetener, buffering agent, and dietary supplement. The pure form of glycine is moderately toxic by the IV route and mildly toxic by ingestion. Systemic absorption of glycine irrigation solutions can lead to disturbances of fluid and electrolyte balance and cardiovascular and pulmonary disorders. LD50 (mouse, IP): 4.45 g/kg LD50 (mouse, IV): 2.37 g/kg LD50 (mouse, oral): 4.92 g/kg LD50 (mouse, SC): 5.06 g/kg LD50 (rat, IV): 2.6 g/kg LD50 (rat, oral): 7.93 g/kg LD50 (rat, SC): 5.2 g/kg
Incompatibilities
Glycine may undergo Maillard reactions with amino acids to produce yellowing or browning. Reducing sugars will also interact with secondary amines to form an imine, but without any accompanying yellow-brown discoloration.
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Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.
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