Glycerine Fatty Acid Ester

Category

Emulsifier; Stabilizer; Thickener; Defoamer, etc

Grade

Pharmceutical Excipients

UNII

NA

Chemical Name

/

Synonyms

/

Administration route

Topical

Dosage Form

Topical preparations

Stability and Storage Conditions

Closed, away from light, stored in a cool and dry place; Avoid contact with oxides and keep away from ignition sources.

Commonly used amount and the maximum amount

The use concentration is generally 0.1~15%.

Source and Preparation

This product is found in natural foods and commercially available products are synthetic; Or from the reaction of fatty acid with excess glycerol by catalytic heating; Or it is obtained by transesterification reaction of grease and glycerol by catalytic heating. At present, sodium hydroxide is usually used as catalyst, which is heated to 200~220℃ in vacuum and nitrogen stream, reacts for 30~60min, and then neutralizes and cools to 90℃ with phosphoric acid. After removing free fatty acids, it is heated at 150℃ for a short time to remove impurity and volatiles. The results contained 40 ~50% monotriglyceride, the rest was diglyceride and a small amount of triglyceride. If the molecular distillation can be obtained with 90% - 95% monoglycerol ester products. The commercially available commodities are mixtures containing mono-diglycerides and a small amount of triglycerides, and the mono-triglycerides shall not be less than 40.0%. This product may contain an appropriate stabilizer.

Safety

This product is non-toxic, non-irritating to skin, ADI does not make restrictions.

Incompatibilities

The product is compatible with oxidizing substances and heavy metal salts.