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DL-Dithiothreitol
Product Details
Category
Antioxidant Cosmetic Chemicals
Molecular Formula
C4H10O2S2
CAS Number
3483-12-3
Synonyms
threo-1,4-Dimercapto-2,3-butanediol, Cleland’s reagent, DTT
Purity
≥98%
Solubility
H2O: soluble 50 mg/mL, clear, colorless to very faintly yellow
Quality Level
200
Storage
2-8°C
Boiling Point
125 °C
Melting Point
41-44 °C (lit.)
Density
1.04 g/mL at 20 °C
Product Description
An excellent reagent for maintaining SH groups in reduced state; quantitatively reduces disulfides. DTT is effective in sample buffers for reducing protein disulfide bonds prior to SDS-PAGE. DTT can also be used for reducing the disulfide bridge of the cross-linker N,N′-bis(acryloyl)cystamine to break apart the matrix of a polyacrylamide gel. DTT is less pungent and is less toxic than 2-mercaptoethanol. Typically, a seven fold lower concentration of DTT (100 mM) is needed than is used for 2-mercaptoethanol (5% v/v, 700 mM).
EC Number
222-468-7
Molecular Weight (g/mol)
154.25
Flash Point
>230 °F
Physical State
Powder
MDL number
MFCD00004877
NACRES
NA.21
InChI Key
VHJLVAABSRFDPM-UHFFFAOYSA-N
SMILES
O[C@H](CS)[C@H](O)CS
InChI
1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m1/s1
Hazard Codes
Xn
WGK Germany
3
RTECS
EK1610000
HS Code
29309099
Water Solubility
Freely soluble
Color
White
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Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.
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