α-cyclodextrin

Category

Solubilizing Agents; Stabilizing Agents

Molecular Formula

(C6H10O5)6

Molecular Weight

972.84

Grade

Pharmceutical Excipients

Description

Cyclodextrins occur as white, practically odorless, fine crystalline powders, having a slightly sweet taste. Some cyclodextrin derivatives occur as amorphous powders.

UNII

Z1LH97KTRM

Chemical Name

α-cyclodextrin

CAS Number

10016-20-3

Synonyms

alfadexum; alpha-cycloamylose; alpha-cyclodextrin; alpha-dextrin; Cavamax W6 Pharma; cyclohexaamylose; cyclomaltohexose

Administration route

Injection

Dosage Form

Injection preparations

Source and Preparation

Cyclodextrin is prepared by enzymolysis of amylase using special bacteria. The first step in the preparation of cyclodextrin (food grade), the starch paste is prepared by cyclodextrin glucose-transferase (CGTase, EC 2.4.1.19, CAS 9030-09-5) under controlled pH and temperature conditions. CGTase is derived from recombinant Escherichia coli. CGTase gene of Bacillus occitorella was latent. Alphacyclodextrin is precipitated by the addition of 1-decyl alcohol in an enzymatic reaction. Purification is obtained by solubility in water and reprecipitation. The added 1-decanol was separated from afacyclodextrin by reanalysis and steam distillation. Finally, afacyclodextrin was obtained by crystallization and white powder purity ≥ 98.0%.

Applications

Mainly used for injectable preparations; However, because its cavity is the smallest among cyclodextrins, inclusion complexes can only be formed with relatively few molecules of small size. Fiber supplement administration; The carrier of a spice (an admixture of a spice); Carrier; Stabilizer or solvent enhancer; Vitamins and fatty acids; Improve the taste in drinks.

Safety

a-Cyclodextrin LD50 (rat, IP): 1.0 g/kg LD50 (rat, IV): 0.79 g/kg

Incompatibilities

The presence of cyclodextrin in aqueous solution may reduce the activity of some antibacterial preservatives.