Copovidone

Category

Binder Excipients

Molecular Formula

(C6H9NO)n

Molecular Weight

(C6H9NO)n＞1000000

Grade

Pharmceutical Excipients

Description

Copovidone is a white to yellowish-white amorphous powder. It is typically spray-dried with a relatively fine particle size. It has a slight odor and a faint taste.

UNII

D9C330MD8B

Chemical Name

Acetic acid ethenyl ester, polymer with 1-ethenyl-2-pyrrolidinone

CAS Number

25086-89-9

Administration route

Oral

Dosage Form

Oral tablets, oral film-coated tablets, sustained action

Stability and Storage Conditions

Copovidone is stable and should be stored in a well-closed container in a cool, dry place.

Source and Preparation

Copovidone is manufactured by free-radical polymerization of vinylpyrrolidone and vinyl acetate in a ratio of 6 : 4. The synthesis is conducted in an organic solvent owing to the insolubility of vinyl acetate in water.

Applications

Copovidone is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations. In tableting, copovidone can be used as a binder for direct compression and as a binder in wet granulation. Copovidone is often added to coating solutions as a film-forming agent. It provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier.

Safety

Copovidone is used widely in pharmaceutical formulations and is generally regarded as nontoxic. However, it is moderately toxic by ingestion, producing gastric disturbances. It has no irritating or sensitizing effects on the skin. A study was conducted to look at the carcinogenicity and chronic toxicity of copovidone (Kollidon VA 64) in Wistar rats and Beagle dogs. The results of these studies demonstrated the absence of any significant toxicological findings of high dietary levels of copodivone in rats and dogs, resulting in no-observed-adverse-effect levels of 2800 mg/kg body-weight/day in rats and 2500 mg/kg body-weight/day in dogs, the highest doses tested.
LD50 (rat, oral): >0.63 g/kg

Incompatibilities

Copovidone is compatible with most organic and inorganic pharmaceutical ingredients. When exposed to high water levels, copovidone may form molecular adducts with some materials; see Crospovidone and Povidone.