Ceftriaxone Sodium Sterile

Molecular Formula

C18H16N8Na2O7S3·31/2H2O

Molecular Weight

661.58

Grade

Pharmaceutical grade

Description

Ceftriaxone disodium salt is a third generation semisynthetic cephalosporin antibiotic, which is chemically synthesized form 7-aminocephalosporanic acid (7-ACA). It has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria, and is generally more active against Gram-negative bacteria than the first and second generation cephalosporins. It has increased stability to β-lactamases compared with the first and second generation cephalosporins. Incorporation of the triazine substituted side chain into the 3-position of the cephalosporin nucleus markedly prolong serum half-life.

Chemical Name

Ceftriaxone Disodium Salt Hemiheptahydrate

CAS Number

104376-79-6

Synonyms

Ceftriaxone sodium, Disodium (6R,7R)-7-[[(2Z)-(2-aminothiazol-4-yl)(methoxyimino)acetyl]amino]-3-[[(2-methyl-6-oxido-5-oxo-2,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 3.5 hydrate, 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, sodium salt, hydrate (2:4:7), (6R,7R)-, 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, disodium salt, hydrate (2:7), (6R,7R)- (9CI), Ceftriaxone disodium hemiheptahydrate, 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, disodium salt, hydrate (2:7), [6R-[6alpha,7beta(Z)]]-

Stability and Storage Conditions

Light Sensitive;Stable under proper conditions.

Applications

Ceftriaxone disodium salt is a third generation semisynthetic cephalosporin antibiotic, which is chemically synthesized form 7-aminocephalosporanic acid (7-ACA). It has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria, and is generally more active against Gram-negative bacteria than the first and second generation cephalosporins. It has increased stability to β-lactamases compared with the first and second generation cephalosporins. Incorporation of the triazine substituted side chain into the 3-position of the cephalosporin nucleus markedly prolong serum half-life.

Safety

orl-rat LD50:>10 g/kg
scu-rat LD50:>5 g/kg
ivn-rat LD50:1900 mg/kg