Carboxymethylcellulose Calcium

Category

Stabilizers; Suspensions; Disintegrants for tablets and capsules; Viscosifiers; Water-absorbing Agentss

Grade

Pharmceutical Excipients

UNII

NA

Chemical Name

Cellulose, carboxymethyl ether, calcium salt

CAS Number

9050-04-8

Synonyms

Calcium carboxymethylcellulose; calcium CMC; CaCMC

Administration route

Oral

Dosage Form

Oral tablet

Stability and Storage Conditions

Calcium carboxymethyl cellulose is a stable substance despite its hygroscopicity. Store in a well-sealed container in a cool, dry place.

Source and Preparation

Cellulose obtained from wood pulp or cotton fibers is carboxymethylated and then converted into calcium salts. Graded and crushed according to the degree of carboxymethylation.

Applications

Calcium carboxymethyl cellulose is mainly used in tablets. As a binder, diluent and disintegrator. Although calcium carboxymethyl cellulose is insoluble in water, it is an effective tablet disintegrator because it expands to several times its original volume upon contact with water. For use in tablets, the maximum use concentration is 15% (w/w); Above this concentration, the hardness of the tablet decreases. Calcium carboxymethyl cellulose also has other uses similar to sodium carboxymethyl cellulose; For example, it is used as a suspension aid or tackifier in oral and topical pharmaceutical preparations.