Carbomer Copolymer

Category

Stabilizer; Base; Suspending Agents; Binder; Coating Agents; Emulsifier; Thickener; Dispersant

Grade

Pharmceutical Excipients

UNII

NA

Chemical Name

Carbomer Copolymer

CAS Number

9003-01-4

Synonyms

EP(CARBOMERS), NF((Carbomer934), (Carbomer934P), (Carbomer940), (Carbomer 941) , (Carbomer 1342), (Carbomer Copolymer), (Carbomer Homopolymer), (Carbomer Interpolymer)〕

Administration route

Oral; general external; tongue administration; rectum, cavity, urethra; ophthalmic; dental external; otolaryngology

Dosage Form

Oral; general external use; tongue administration; rectum, cavity, urethra; ophthalmic medicine; dental external use and oral medicine; otolaryngology medicine.

Stability and Storage Conditions

Store in airtight container.

Commonly used amount and the maximum amount

Maximum dosage: oral: 150mg; general external use: 48.99mg/g; tongue administration: 15mg/g; rectum, cavity, urethra 130mg; ophthalmic medicine: 4mg/g; dental external use and oral medicine: 40mg/g; ear and nose Clinical medicine: 6mg/g.

Applications

Carbomer can be used as a binder and coating material for granules and tablets, a matrix for external preparations, an emulsifier (for the preparation of O/W emulsions for external use), a viscosity enhancer and suspending agent, and a sustained and controlled release material ( The sustained and controlled release of carbomer is based on its swelling and gel-forming properties). Carbomer can also be salted with basic drugs to form a soluble gel to exert a sustained and controlled release effect. It is especially suitable for the preparation of sustained-release liquid preparations, such as eye drops and nasal drops. Carbomer is also used in the preparation of mucoadhesive tablets to achieve a sustained release effect, and it has a better effect when used in combination with some water-soluble cellulose derivatives.

Safety

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Incompatibilities

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