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Peptides & Proteins Delivery System Development

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At CD Formulation, we provide a wide array of services customized to cater to the distinct formulation requirements of peptide and protein drugs, including injectable formulations, inhalable systems, nanoparticle formulations, and more. Through our innovative solutions, we strive to maximize the therapeutic potential of peptides and proteins, ensuring optimal delivery and efficacy.

Challenges of Peptide & Protein Delivery

  • Peptides and proteins are fragile molecules that can be easily degraded by enzymes in the body before reaching their target site.
  • These large hydrophilic molecules generally have poor absorption across biological barriers like the intestinal epithelium or blood-brain barrier when administered orally or systemically.
  • Repeated administration can trigger an immune response to these large foreign molecules.
  • Short-acting profiles often require frequent and higher dosing which impacts patient compliance and increases costs.
  • Specialized routes like injection, inhalation or implant devices are sometimes required but impact usability.

What Can We Do for Peptide & Protein Formulation Development?

Peptide & Protein Formulations Development – CD Formulation

We can develop injectable peptide and protein formulations, including solutions, suspensions, and emulsions, ensuring stability, compatibility, and controlled release for efficient delivery.

Our team can design oral peptide and protein formulations, such as tablets, capsules, or nanoparticles, to enhance bioavailability, protect against enzymatic degradation, and improve patient compliance.

We excel at formulating peptides and proteins for topical and transdermal delivery, optimizing formulation properties to ensure effective penetration and targeted delivery to the desired site.

We have expertise in developing inhalable peptide and protein formulations, such as dry powder inhalers or nebulizers, for targeted delivery to the respiratory system.

Our capabilities extend to the development of implantable peptide and protein formulations, enabling sustained release and localized delivery for long-term therapeutic effects.

We can formulate peptides and proteins into liposomes or nanoparticles, enhancing stability, bioavailability, and targeted delivery to specific tissues or cells.

  • Combination Formulations

We have the expertise to develop combination formulations, incorporating peptides or proteins with other active ingredients or therapeutic modalities for synergistic effects and improved therapeutic outcomes.

Our Peptide & Protein Formulation Analysis Services

Our Peptide & Protein Formulation Analysis Services

  • Particle Size Analysis
  • Zeta Potential Analysis
  • Encapsulation Efficiency
  • Release Kinetics
  • Stability-Indicating Assays
  • Aggregation Assessment
  • Secondary Structure Analysis
  • Sterility Testing
  • Accelerated Stress Testing

Our Platforms for Peptide & Protein Formulation Development

Polymer Engineering We have expertise in designing novel polymers and customizing existing materials for controlled/targeted delivery applications.
Nanotechnology Our nanomedicine platform utilizes lipid-/polymer-based nanovesicles, polymeric nanoparticles, hydrogels for encapsulation.
Pulmonary Drug Delivery Capabilities for customized dry powder, nebulized liquid formulations optimized for effective lung deposition.
Bioprinting 3D bioplotting and inkjet printing allow precise architecture of 3D tissues and personalized pouches/tablets.
Computational Modeling Molecular dynamics and PBPK modeling guide rational design by predicting formulation-biologic interactions.
Analytical Technologies State-of-art characterization tools like HPLC, DLS, CD, SEM for thorough product profiling.
Process Development Capabilities for manufacturing demonstration batches, quality by design principles.

Highlights of Our Peptide & Protein Delivery System Development Services

  • Through our formulation design, we can improve the safety, compliance and reduce the medical costs of peptide and protein drugs.
  • Our platform supports the development of novel dosage forms such as nanoparticles, hydrogels and long-acting depots.
  • Our formulation strategies such as polymer conjugation and encapsulation technologies help override biological barriers and direct payloads to desired sites for improved efficacy.
  • Through molecular level design of stabilizing excipients and controlled release systems, we can enhance the stability of fragile biologics.

CD Formulation is a leading formulation development company dedicated to advancing the delivery of peptide and protein therapeutics. Whether you need help stabilizing a biologic, tuning its pharmacokinetics, or enhancing its uptake into tissues, our formulation scientists can help our clients overcome their challenges and translate more peptide and protein candidates into novel treatments. Contact us to discuss how we can apply our innovative capabilities to your complex biologics program!

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