Peptide & Protein Inhaled Formulation Development

Pulmonary administration offers opportunities for treating local lung conditions, as well as systemic illnesses via absorption. At CD Formulation, our scientists have extensive experience crafting dry powder and nebulized inhalable formulations to maximize this non-invasive route's potential. Whether exploring new biologic treatments or scaling existing products, our customized services provide full support. We optimize powder properties like particle size and aerosol performance.

Why are Peptides and Proteins Formulated for Inhalation?

• Peptides and proteins can be formulated into inhalation preparations to offer several advantages in the treatment of respiratory conditions.
• Inhalation allows for direct delivery of peptides and proteins to the lungs, the site of action for many respiratory diseases.
• Inhalation bypasses the digestive system and offers enhanced bioavailability for peptides and proteins compared to other routes of administration.
• Inhalation is a non-invasive route of drug administration, which enhances patient compliance and convenience.
• Inhaled preparations are well targeted and can reduce toxic and side effects.

Inhalation Formulations We Can Develop

Our Micronization Technology Platforms

• Grinding Technology

For peptide and protein samples, such as calcitonin, we can prepare coarse powder by freeze-drying, and then spray-mill to produce inhalable particles.

• Spray Drying Technology

A solution containing active drug molecules can be spray dried in one step to obtain dry fine powder, which is suitable for the preparation of DPI for polypeptide and protein drugs.

• Spray Freeze Drying Technology

For thermally unstable drugs (such as proteins, peptides and DNA, etc.), we can use spray freeze-drying technology to make the prepared particles have better stability and dispersion.

• Supercritical Fluid Technology

In order to obtain micro powder with suitable particle size, we treat the peptide or protein solution and mix it with a supercritical fluid (such as carbon dioxide). The SCF containing the solute is rapidly decompressed, which will cause the solute to form a highly supersaturated state and generate a large number of fine crystals.

Advantages of Our Peptide & Protein Inhaled Formulation Development

• We possess extensive knowledge and experience in the field of inhalation drug delivery.
• Our services are designed to meet the specific needs of each client, allowing for tailored formulations.
• We strive to develop user-friendly inhalation devices and formulations that are easy to use, promoting patient adherence to prescribed treatment regimens.
• Our expertise extends to a diverse range of peptides and proteins, allowing us to develop inhalation dosage forms for various therapeutic applications.
• Our team provides ongoing support, addressing any concerns or challenges that arise.

With years of experience and a dedicated team of experts, CD Formulation specializes in creating innovative and customized inhalation formulations for peptides and proteins. If you'd like to discuss how we can help advance your peptide or protein candidate's lung delivery application, please contact us. We are happy to explore innovative solutions tailored to your unique molecules and goals.