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Peptide & Protein Liquid Formulation Development

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CD Formulation specializes in creating customized liquid formulations for peptides, proteins, and other biologics. Today our full-service capabilities span from preclinical studies to clinical trials and commercial manufacturing. While growing in scale, we maintain a hands-on, scientifically rigorous, client-focused approach to finding the right formulation fit for each new molecule.

Types of Peptide & Protein Formulations We Specialize in

Injection

  • Injection

Some peptide & protein drugs can regulate physiological functions, provide immune protection, and promote cell growth and development, such as insulin, interferon, and albumin. For these drugs, we can develop solution formulations for injection or infusion.

Oral Delivery

  • Oral Delivery

When it comes to oral formulations of peptides and proteins, emulsions and suspensions are commonly utilized. These liquid preparations serve various health-promoting roles in nutrition and wellness.

Eye Drops

  • Eye Drops

Polypeptides or proteins have application prospects in the field of eye disease treatment. There have been many studies and developments on peptide and protein eye drops, which are mainly used to treat eye diseases and have the functions of protecting the cornea and inhibiting inflammation.

Our Peptide & Protein Liquid Formulation Development Services

CD Formulation provides complete formulation solutions including:

  • Prototype design and analytical testing
  • Stability optimization
  • Process scale-up and technology transfer
  • Lyophilized formulation conversion
  • By managing the entire liquid formulation lifecycle in-house, we efficiently develop optimized platforms tailored to your biologic’s needs from early phase to market readiness.

Our Peptide & Protein Liquid Formulation Development Process

  • Design

    Excipients are selected based on the biologic's properties and desired characteristics.

  • Prototyping

    Various formulations are rapidly prepared and undergo initial analytical testing.

  • Characterization

    Lead candidates are evaluated for critical physicochemical properties. Stability is assessed with techniques like DSC, FTIR and HPLC.

  • Optimization

    Formulations are refined based on iterative analytical feedback to improve stability and performance.

  • Transfer

    Manufacturing processes and analytical methods are transferred to clients for clinical manufacturing and testing.

Our Liquid Formulation Platforms

  • Aqueous single-phase vehicles like saline buffers, surfactants, and stabilizers. These simple liquid forms provide a versatile starting point.
  • Emulsions and microemulsions use oils and amphiphiles to encapsulate hydrophobic compounds.
  • Liposomes and lipid nanoparticles where the drugs intercalate into the lipid membrane structure for improved circulation.
  • Polymer-based platforms such as PEGylated and dendrimer systems that enhance solubility and half-life.
  • Suspensions containing insoluble complexed or precipitated protein stabilized for injection.

Advantages of Our Peptide & Protein Liquid Formulation Development Services

  • The customizable nature of our liquid formulation development services is an ideal tool for optimizing and innovating protein and peptide delivery and stability.
  • Our extensive experience allows us to engineer aqueous or lipid-based vehicles matched to each biologic's unique properties and program needs.
  • With our liquid preparation services, we can overcome formulation hurdles and accelerate progression from the lab to the clinic.
  • Liquid formulation problem-solving is grounded in science, not trial and error. Our expertise means faster solutions.

Bringing innovative biologics like peptides and proteins to patients starts with the right formulation. At CD Formulation, we combine proven methodology with customization to create optimized liquid vehicles perfect for your program. Our formulation experts are passionate about enabling your biologics to advance safely and effectively. To learn more about collaborating on your liquid formulation, contact us today!

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