Benzethonium Chloride

Category

Antibacterial Agents; Preservative; Disinfectant

Molecular Formula

C27H42ClNO2

Molecular Weight

448.1

Grade

Pharmceutical Excipients

UNII

PH41D05744

Chemical Name

N, N-Dimethyl-N-[2-[2-[4-(1, 1, 3, 3-tetramethylbutyl)phenoxy]ethoxy]eyhyl]benzene- methanaminium chloride

CAS Number

121-54-0

Administration route

AURICULAR (OTIC); INTRAMUSCULAR; INTRAVENOUS; OPHTHALMIC; Topical

Dosage Form

Solution; Injection; Soultion/drops; Cream

Stability and Storage Conditions

Benzoxolium chloride is stable and an aqueous solution can be autoclaved. Store bulk apis air-tight in a cool, dry and dark place.

Source and Preparation

2-[2-[4-(1, 1, 3, 3-tetramethylbutyl) phenoxyl] ethoxy] ethyl chloride was synthesized by condensation of P-diisobutylphenol with β, β '-dichlorodiethyl ether under alkaline catalysis. The product is then converted into the corresponding tertiary amine by alkaline dimethylamine. After distillation and purification, it is dissolved in an appropriate amount of organic solvent and treated with benzyl chloride. The product is precipitated.

Applications

Benzoxonium chloride is a quaternary ammonium compound used as an antimicrobial agent in pharmaceutical preparations. In general, solutions with concentrations of 0.01.to 0.02% w/v can be used as antimicrobials for injection, eye preparations and ear preparations. Benzoxonium chloride can also be used as a wetting agent, solvent enhancer and topical disinfectant. In cosmetics such as deodorants, benzoxalammonium chloride at concentrations greater than 0.5% w/v can also be used as antibacterial agents. The physical properties and applications of benzoxonium chloride are similar to those of other cationic surfactants such as cetroxonium bromide.

Incompatibilities

Benzoxonium chloride should not be compatible with soap and other anionic surfactants. When inorganic acids and some salt solutions are added, the solution with a concentration higher than 2% w/v will precipitate.