Alitame

Category

Sweetening agent

Grade

Pharmceutical Excipients

UNII

NA

Chemical Name

L-α-Aspartyl-N-(2, 2, 4, 4-tetramethyl-3-thietanyl)-D-alanina-mide anhydrous; L-α-Aspartyl-N-(2, 2, 4, 4-tetramethyl-3-thietanyl)-D-alanina-mide hydrate

CAS Number

80863-62-3

Stability and Storage Conditions

Alitame is stable at dry room temperature and degrades at high temperature or low pH. In the first stage, allose degrades to aspartic acid and alanine (under caustic conditions), and in the second stage it degrades slowly, first to β-aspartic acid isomers and then to aspartic acid and alanine. At pH 5 - 8, the half-life of alose solution at 23℃ is about 4 years. At pH 2, the half-life of allose solution at 23℃ is 1 year. Allocate should be kept in an airtight container in a cool and dry place.

Source and Preparation

Alitame can be synthesized in a variety of ways. For example, dissolve 3- (d-alanamide) -2, 2, 4, 4-tetramethylthiocentine (thietane) in water, then add L-aspartic acid n-thiocarboxylic anhydride in sections, stir vigorously, maintain pH 8.5 - 9.5, then adjust pH to 5.5. P-toluenesulfonic acid monohydrate was added slowly over a period of more than one hour. Filter and collect the precipitated toluene sulfonate. To obtain alitame from salt-type alitame, a mixture of Amberlite LA-1 (liquid anion exchange resin), methylene chloride, deionized water, and alitame salt is stirred for 1 hour in a solution divided into two distinct layers. The water layer is treated with toner, the clarified solution is filtered and cooled to crystallize the alacrine. In addition, D-alanine, which has been protected by NH2, is condensed with tetramethylthiacyclic acid, and then linked to the protective L-aspartic acid analogue, to obtain a crude alysaccharide. The crude product is ready to be refined.

Applications

Allocate is about 2, 000 times sweeter than table sugar. It is low in energy, containing 6kJ (1.4kcal) of calories per gram of Aleck. Alose is now used mainly in food and confectionery, with concentrations ranging from 20 to 200 PPM.

Incompatibilities

Alitame is not compatible with REDOX substances or strong acids and bases.