Antibody Delivery System Development

• Antibody Expression and Purification

We have expertise in recombinant antibody expression using various host systems such as mammalian cells, yeast, or bacteria. Our team optimizes expression conditions to maximize yield and quality. Additionally, we employ advanced purification techniques, including affinity chromatography, size-exclusion chromatography, and ion exchange chromatography, to obtain highly purified antibodies.

• Antibody Formulation Development

We specialize in the development of antibody formulations, catering to various administration routes such as injections, powder injections, and inhalation preparations. By leveraging cutting-edge formulation technologies, we help clients successfully navigate antibody development into different administration formats, allowing for long-acting depots, precise pulmonary targeting, and versatile dosage forms.

• Antibody Nanoparticle Development

CD Formulation has extensive experience engineering a variety of nanoparticles. Our formulation scientists can customize nanoparticles from polymers, lipids or inorganic nanomaterials with properties tailored to specific antibodies and applications. We also incorporate surface modifications to improve targeting capabilities and minimize immunogenicity.

• Antibody Complexes Development

Our capabilities extend to the development of antibody complexes, enabling the formation of versatile therapeutic entities. We utilize our antibody engineering and multivalent display technologies to conjugate antibodies to other biomolecules such as peptides, proteins, and drug moieties.

• Antibody-Modified Delivery Vehicles Development

Our team of formulation scientists can functionalize nanoparticles, liposomes, viral vectors, and other biomimetic systems with antibodies to enable homing to specific antigens overexpressed in diseased cells and tissues. We optimize the density, orientation, and conjugation methods of the antibody modifications to preserve targeting ability.

• Antibody Humanization Service

Leveraging our expertise in protein engineering and monoclonal antibody development, CD Formulation provides comprehensive humanization services. We have the capabilities to analyze antibody sequences, identify variable and constant regions derived from non-human species, and graft them onto human frameworks using structure-guided computational design and molecular modeling.