Antibody Humanization Service
InquiryAt CD Formulation, our experienced team of scientists has expertise in antibody engineering and bioinformatics to carefully design antibody humanized strategies that enable a seamless transition from non-human sources to fully human molecules. Our comprehensive humanization process covers antibody framework optimization, CDR grafting, and structure-guided engineering, resulting in next-generation therapeutics with enhanced safety and reduced risk of adverse immune reactions.
Why Do Antibodies Need to be Humanized?
Antibody humanization plays a pivotal role in therapeutic antibody development. While non-human antibodies, such as those derived from mice or other species, possess exceptional binding affinity and specificity, their immunogenicity in humans can limit their clinical application. Antibody humanization offers a solution to bridge this gap by preserving the desirable binding characteristics of non-human antibodies while minimizing their immunogenic potential.
Types of Antibody Humanization Services We Can Provide
Our Antibody Humanization Services Process
To make our service smoother, we need to start the process by thoroughly understanding your therapeutic goals and reviewing any details you can provide about the antibody sequence itself, as well as any discovered functional or structural features.
- Humanized Strategy Design
Depending on the type of antibody humanization selected by the customer, our team combines bioinformatics, computational modeling, and immunogenicity assessment to design a custom humanization strategy.
We continuously optimize the antibody sequence during the development of humanized antibodies to ensure the compatibility of the antibody with the human immune system while maintaining the integrity and stability of the antibody.
- Structure-guided Humanization
Based on structural analysis and molecular modeling, we made reasonable design modifications to further improve the humanized antibody.
Immunogenicity Assessment
We can help clients evaluate the immunogenic potential of humanized antibodies and analyze T cell epitopes and MHC binding to mitigate risks associated with immunogenicity.
We provide you with a selection of humanized antibody candidates that have undergone rigorous evaluation and optimization, enabling you to make informed decisions regarding the most promising candidates for further development.
Advantages of Our Antibody Humanization Services
- Flexible humanized antibody preparation strategies
- Strict quality control system
- Comprehensive experimental technicians
- High-throughput screening and flexible library panning strategies
- Complete upstream and downstream services
CD Formulation's antibody humanization services leverage the latest computational modeling and structure-guided design techniques to convert non-human antibodies into optimized human therapeutics. Our extensive expertise enables us to re-engineer the antibody sequence to maximize human compatibility while retaining target affinity and specificity. We utilize advanced bioinformatics tools to select optimal human antibody frameworks and precisely graft the complementarity-determining regions from your original antibody. If you need our services or have any question about our technology, please feel free to contact us!
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