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Antibody Complexes Development

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Antibody complexes have great application potential in the field of difficult-to-treat and drug-resistant diseases. CD Formulation has a group of interdisciplinary outstanding scientists. We have conducted in-depth research in the field of antibody complex development, explored new knowledge in the industry, and accumulated rich experience, only to provide customers with better antibody complex development services.

What are Antibody Complexes?

An antibody complex is a combination of an antibody and another molecule. By pairing an antibody with another antibody, antigen, or small-molecule compound, we can create a formulation that outperforms each component alone. The synergistic effects open up possibilities for tackling diseases in new ways. Antibody complexes show particular promise for advancing cancer immunotherapies, calming autoimmune overreactions, and neutralizing stubborn infections.

Types of Antibody Complexes We Can Develop

Antibody Complexes Types at CD Formulation

By combining different antibodies together, we can achieve better effects and cover more targets. We select antibodies with different properties according to different disease targets and optimize the combinations.

  • Antibody-antigen Complex Development

Antibody-antigen complexes are formed when an antibody specifically binds to its target antigen. We often combine this technology with vaccines to increase their effectiveness. To evaluate how well antibody-antigen complexes work, we perform rigorous tests in test tubes and living creatures to check their functions, including how well the antibody binds to the antigen, how well it neutralizes the disease-causing agent, and more.

  • Antibody-compound Complex Development

The combined administration of antibodies and small molecule inhibitors has great potential in the treatment of tumors and other diseases. The synergistic effect of the two can overcome and reduce drug resistance. We can identify disease targets according to customer needs, conduct literature research, and select appropriate combinations of antibodies and small-molecule compounds. Based on the properties of the antibody and compound, we develop the most appropriate complex dosage form for our customers, providing important insights into the efficacy, safety and clinical translation potential of the complex.

Our Technology Platforms for Antibody Complexes Development

  • Our experts master hybridoma technology for generating monoclonal antibodies with target specificity and high affinity.
  • CD Formulation has a rich variety of phage display libraries that can help customers screen antibodies with different functions and properties.
  • Our comprehensive compound synthesis and quality analysis platform can meet customers' customized compound synthesis needs.
  • Our company is equipped with a cutting-edge formulation technology platform that can be used for the formulation of antibody complexes of different properties.

Highlights of Our Antibody Complexes Development Services

  • Enhance Therapeutic Effect

Compared with single-target intervention, we formulate antibodies into complexes, which may help customers enhance the therapeutic effect of a single drug.

  • Expand Therapeutic Potential

The various types of antibody complexes we develop are engineered to expand the therapeutic potential of biologics by targeting multiple disease-relevant components.

  • Versatility and Adaptability

Whether your goal is cancer or another complex disease, we have the expertise and resources to address your specific challenges.

CD Formulation focuses on providing high-quality antibody complex development services. We are committed to providing customers with efficient and reliable solutions that meet their specific needs and create maximum value for them. For more information or interest in our services, please contact us!

References

  1. Wang X.Y.; et al. From therapeutic antibodies to immune complex vaccines. NPJ Vaccines. 2019, 4:2.
  2. Akhouri R.R.; et al. Antibody complexes. Subcell Biochem. 2019, 93:23-51.
  3. Gao F.; Yang C. Monoclonal antibodies and their combinations with PD-1/PD-L1 inhibitors in clinic. Curr Cancer Drug Targets. 2020, 20(1):3-18.
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