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Chemical Enhancement Technology for Transdermal Delivery

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Transdermal drug delivery offers a steady, controlled release of drugs through the skin, allowing for targeted treatment of either localized areas or the entire body. This method avoids the inconveniences and risks associated with oral or injection-based therapies, while enhancing drug bioavailability. However, the skin's outermost layer, the stratum corneum, presents a barrier to many drugs, making effective absorption through the skin a key challenge. CD Formulation is at the forefront of overcoming this barrier with advanced chemical technologies that improve transdermal delivery efficiency, providing cutting-edge R&D services for pharmaceutical companies and researchers.

Introduction to Chemical Enhancement Technology for Transdermal Delivery

Chemically enhanced transdermal drug delivery changes the stratum corneum with special chemicals. These chemicals help drugs get in. They work by interacting with stratum corneum lipids, making them more fluid, or creating paths for drugs. Ethanol, propylene glycol, and azone are common examples. Each has unique ways to boost drug absorption through the skin.

Fig.1 Classification and mechanisms of action of a variety of different chemical enhancer groups used in the facilitated delivery of drugs transdermally. (Delly Ramadon, et al. 2021)

Key Features of Penetration Enhancers in Transdermal Systems

Fig.2 Features of penetration enhancers. (CD Formulation)

Explore Our Advanced Technology Platform

In our company, our chemical penetration enhancers include but are not limited to the following:

Chemical Enhancers	Specific Information
Surfactants	Tween, Span, oleic acid, dipotassium glycyrrhizinate, soybean lecithin hydrogenated lecithin, etc.
Organic solvents	Diisopropyl adipate, tocosolone, dimethyl isosorbide, etc.
Organic acids and fatty alcohols	Oleic acid, linoleic acid, and lauryl alcohol
Keratin moisturizing and softening agents	Urea, salicylic acid, and pyrrolidone

Stratum Corneum Modification

Based on our technology platform, we can provide the following services for you and your products:

Changing the properties of the stratum corneum can improve the permeability of drugs to the skin

a. Adding lipid excipients to the formulation to prevent water loss.

b. Using humectants to increase skin moisture.

The stratum corneum is altered with chemical penetration enhancers. These enhancers:

a. Use DMSO to speed up how hydrophilic drugs move through SC corneocytes.

b. Azone interacts with stratum corneum lipids, disrupting their arrangement.

c. The stratum corneum is made of lipids and repels water. Using fatty acids like oleic acid and lauric acid boosts drug absorption because they are similar to stratum corneum lipids.

Comprehensive Transdermal Formulation Development Services

Based on our technology platform, CD Formulation is dedicated to the development and engineering of all types of transdermal formulations.

Gel Transdermal Formulation Development

Gel-based transdermal formulations offer efficient drug delivery through the skin, mucous membranes, and cavities. These formulations, often in the form of solutions or emulsions, use biodegradable, non-toxic excipients to create semi-solid or thick liquids.

Transdermal Patch Development

A transdermal patch combines active ingredients with a matrix to deliver drugs through the skin at a controlled rate. We can optimize formulations using advanced techniques and ingredient selection to ensure efficacy and quality in both localized and systemic delivery.

Ointment Transdermal Formulation Development

Ointments are semi-solid topical formulations that blend raw materials with oily or water-soluble bases. Their soft texture and ability to form protective films allow for sustained drug release at targeted sites.

Cream Transdermal Formulation Development

Creams are semi-solid external formulations that dissolve or disperse drugs in an emulsion matrix. Their oil content and texture can vary, offering flexibility in formulation design similar to gels, for diverse applications.

Spray Transdermal Formulation Development

Sprays are drug formulations in suspension, solution, or emulsion form, which are loaded into a device for atomized delivery. They ensure uniform application, fast absorption, and rapid action.

Why Choose CD Formulation for Chemically Enhanced Transdermal Solutions?

We have a professional R&D team dedicated to the research and development of highly efficient, low-toxic, and biocompatible chemical permeation enhancers.
We provide customized development services for transdermal drug delivery systems based on customer requirements. From drug screening, permeation enhancer selection, and nanocarrier design to formulation process optimization, we ensure that the final product meets customer expectations and requirements.
We provide customers with professional consulting services on chemically enhanced transdermal drug delivery technology.

Publication Data

Technology: Nanotechnology

Journal: Nanoscale Adv

IF: 4.6

Published: 2023

Results: Chemical enhancers function by disrupting the lipid bilayer of the SC, interacting with proteins, or modifying the partition coefficient of the drug. These compounds have been widely used in many transdermal products to increase drug permeation. It is necessary, however, to consider the safety of such chemicals. Thus, not all types of chemicals can be used as transdermal enhancers as there are specific requirements for their use in pharmaceutical products. These chemicals must be inert, nontoxic, nonallergenic, nonirritant, preferably elicit rapid effects, be aesthetically accepted, and crucially skin barrier function must recover quickly after the chemicals have been removed.

CD Formulation's chemically enhanced transdermal drug delivery technology has demonstrated significant success across a wide range of applications. We support research and development efforts in areas such as medical aesthetics, where our technology can be applied to the development of freckle treatment and anti-aging formulations. In pain management, our solutions facilitate the creation of transdermal analgesic patches designed for sustained and stable pain relief. Our innovative approaches enable research institutions and pharmaceutical companies to advance the development of both therapeutic and cosmetic transdermal formulations. For more information or project inquiries, please contact us, and our team will respond within three business days.

References

Delly Ramadon, Maeliosa T. C. McCrudden, et al. Enhancement strategies for transdermal drug delivery systems: current trends and applications. Drug Delivery and Translational Research. 2022, 12, 758–791.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.

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