Syrups

Syrups is a concentrated solution of sugar in water or other aqueous solutions. Medicinal syrup is a nearly saturated aqueous solution in which the medicinal substance or drug is dissolved. Basically, it is an oral suspension in liquid form. Medical syrup or medicinal syrup is actually used as a carrier for drugs. It is often used as a flavoring agent for medicines. The syrup should be kept tightly in a cool and dry place after use for preservation. Medicinal syrups are widely used as medicines for children, but there are also pharmaceutical syrups for adults.

Fig.1 Syrups.

The team of CD Formulation is leading experts in all aspects of pharmaceutical formulation development and dosage form optimization, we can accord the characteristics of the API and the development goals of the customers to design the formulation of syrups. CD Formulation can provide you with one-stop services to meet your needs of syrups.

Why Use Syrups?

• Appropriate for any patient of different ages
• The most natural and easiest route of administration
• Economical and safe to the patient
• No nursing is required, which means the patient can take it with no help
• The liquid dosage form is expected for certain types of products like cough medicines

Components of Syrups

• Sweetening agent- the sugar, usually sucrose, or sugar substitute used to provide sweetness and viscosity
• Antimicrobial preservatives
• Viscosity modifier
• Flavorants
• Colorants

The Process of Developing Syrups

Pharmaceutical syrups are produced by mixing purified water, sweeteners, active ingredients (API), aromas, flavors and other ingredients (thickeners) etc. There are four methods of preparing syrups. Based on the physical and chemical properties on the ingredients, the choice of the method is selected. I. Solution with heat. II. Agitation without heat. III. Addition of sucrose to liquid medicament. IV. Percolation method.

The manufacturing process must achieve the following factors:

• Dissolving of the sugars to form a syrup
• Hydration of powdered ingredients
• Blending ingredients of widely different viscosity
• Suspension or dissolving of active ingredients
• The end product must be smooth, agglomerate-free and homogeneous
• Equipment should conform to GMP standards

If you have a requirement about syrups services, please contact us by phone or email, our colleagues will reply to you within three working days.

References

1. Ziémons, E, Mantanus J, Lebrun P, et al. Acetaminophen Determination in Low-Dose Pharmaceutical Syrup by NIR Spectroscopy[J]. Journal of Pharmaceutical & Biomedical Analysis, 2010, 53(3): 510-516.
2. Kulikov A, Verushkin A. Simultaneous Determination of Paracetamol, Caffeine, Guaifenesin and Preservatives in Syrups by Micellar LC[J]. Chromatographia, 2008, 67: 347-355.
3. Wang R, Hartel R. Effects of Moisture Content and Saccharide Distribution on the Stickiness of Syrups[J]. Journal of Food Engineering, 2020, 284: 110067.