Stimulation Response Hydrogel Development

Stimulation Response Hydrogel is a drug delivery system that provides on-demand drug release at a specific time and in a specific amount at a specific location due to its specific environmental response properties. CD Formulation provides professional stimulus-responsive hydrogel development, design, and testing services to help customers better develop their drug delivery systems.

What is Stimulation Response Hydrogel?

Stimulus-responsive hydrogels are sensitive and responsive to external stimuli, i.e., they have both sensing and reactive functions. Sensing function means that the gel can quickly sense and respond to small changes in external environmental conditions, including physical and chemical changes, such as temperature, pH, ionic strength, electric field, light, pressure and concentration of certain special substances - the passive function. After the gel senses these external stimuli, a reversible volumetric phase change or sol-gel phase change occurs, during which the hydrogel volume increases or contracts abruptly, thereby retaining or releasing the drug in the gel network. We can control the timing, quantification, and localization of drug release by controlling the environmental conditions in which the smart polymer hydrogel is placed, so it has broad application prospects in drug control release and other aspects.

Stimulation Response Hydrogel Design

Hydrogels with homogeneous network structure, or with two networks of different properties complementing each other, can improve the homogeneity of the network, which is an effective way to improve the mechanical strength of the gel. When the gel is impacted, stretched or compressed by external forces, the stress concentration at the cross-linked point is easily damaged. If the crosslinking point can slide, then when it is subjected to external force, the stress can be dispersed in the whole network, thus improving its ability to resist external force. The more cross-linking points and the higher the cross-linking density, the more restricted it is and the more difficult it is to move. Therefore, reducing the cross-linking density of polymer chains can improve its activity performance and can effectively shed excessive stress concentration, thus improving its mechanical strength.

• Material Characterization Testing

CD Formulation offers transmission electron microscopy tests to analyze the size and morphology of hydrogels. UV-Vis spectrophotometric analysis is also available.

• In Vitro Release Studies

In vitro release behavior is studied by equilibrium dialysis and drug concentration is measured by high performance liquid chromatography.

Ideal Types of Stimulation Response Hydrogel

Sufficiently large drug loading capacity and the ability to carry a variety of different types of drugs in the West.

Good biocompatibility, biodegradability and safety. Especially as a carrier for internal controlled release drugs, it is required that it can become a small molecule harmless to the body through hydrolysis or enzymatic digestion and be excreted or absorbed through metabolism.

Not only does it respond to one or more conditions of environmental stimuli, but also requires a rapid response.

It is required to respond to environmental stimuli with certain sensitivity and accuracy, i.e., it can respond within a certain range of environmental stimulus changes, and has certain accuracy and repeatability.

It is required to have sufficient mechanical strength and adhesion, so that it is not easy to break or fall off during the pulling process.