Polymersomes Development

Polymersomes are composed of ordered aggregates of amphiphilic block copolymers. A typical polymeric vesicle is a hollow sphere with an aqueous solution in its core, surrounded by a bilayer membrane. The bilayer consists of a hydrated hydrophilic crown located inside and outside the hydrophobic middle part of the membrane, which isolates and protects the fluid core from the external medium. The main methods of preparing polymersomes are the phase transformation method and the thin film hydration method. Polymersomes are characterized by a wide variety of preparation materials, good stability, biodegradability, and versatility, and can transport both water-soluble and hydrophobic drug molecules, such as hydrophilic chemicals, enzymes, proteins and peptides, DNA or RNA, while hydrophobic drugs can be solubilized in the bilayer hydrophobic core.

Fig.1 Schematic illustration of a 3D cross-section of a polymersome. (Lee et al., 2012)

Our Services

CD Formulation can provide customers with development, optimization and characterization testing of polymersomes for drug delivery, design and optimization of polymersomes suitable for specific drug delivery to help accelerate the development of their products.

Polymersomes Development Services for Drug Delivery

CD Formulation can design polymersomes suitable for specific drug delivery and can predict release kinetics based on customer needs. We can customize the formation of specific polymersomes with polymers that respond to a variety of different stimuli including pH, temperature, redox conditions, light, magnetic field, ionic strength and glucose concentration.

Polymersomes Optimization Services

CD Formulation can provide polymer vesicle optimization services to properly modify our customers' products to create sensitivity to external stimuli. We have several years of experience in the drug delivery system technology industry and can provide optimization services and solutions to help accelerate your product development.

Polymersomes Characterization Testing

CD Formulation offers our customers a number of test projects for polymersomes.

• Dynamic/static light scattering tests to determine critical aggregation concentration, vesicle size and size distribution.
• Optical or electron microscopy tests to assess polymer vesicle size, morphology and homogeneity.
• Confocal laser scanning microscopy (CLSM) tests to provide 3D stacked vesicle images.

Applications of Polymersomes in Drug Delivery Systems

Polymersomes Encapsulate Small Molecule Drugs

Large water-soluble cavities and thick bimolecular vesicles provide encapsulation sites for hydrophilic and hydrophobic drugs, respectively.

Polymersomes Encapsulate Genes

Higher transfection efficiency and lower immune response compared to viral gene vectors, allowing for continuous expression of heterologous genes.

Polymersomes Delivery of Protein-Based Drugs

About CD Formulation

CD Formulation provides integrated innovation solutions from strategy to implementation to help you increase opportunities and address challenges. Through our in-depth experience in many different industries, including consumer and technology, we bring innovative solutions and cross-industry best practices to drug development. If you have a requirement about our services, please contact us by phone or email, our colleagues will reply to you within three working days.

Reference

1. Lee, Jung Seok, and Jan Feijen. Polymersomes for drug delivery: design, formation and characterization[J]. Journal of controlled release, 2012, 161(2): 473-483.