Parenteral Suspensions

Parenteral administration is the introduction of a nutrient, drug or other substance into the body rather than through the digestive tract. Unlike oral or rectal administration, the introduction of drugs into the body via parenteral administration poses greater risks. Parenteral suspensions are dispersed, heterogeneous systems containing insoluble drug particles and are dosage forms containing low solubility drugs. The suspension form improves the solubility and stability of the drug, and the sulfonated form has a larger surface area. Parenteral suspensions have a longer onset of action compared to solutions. Most parenteral suspensions are designed for intramuscular or subcutaneous administration.

Our Services

Parenteral suspensions of poorly water-soluble salts for intramuscular injection maintain therapeutic drug concentrations over a long period of time. In vitro drug dissolution tests are a prerequisite for assessing batch-to-batch differences and for ensuring drug release during formulation development. CD Formulation offers specific services including the following:
Performance testing of suspensions.
Data reporting and analysis.

CD Formulation's team is a leading expert in all aspects of drug formulation development and dosage form optimization, and we can design parenteral suspensions formulations based on the nature of the drug and the development goals of our customers.

Application of Suspensions

• Some drugs are insoluble or partially soluble, there is the application of suspension.
• Some of the drugs are very bitter or unpleasant taste. Suspension helps to mask the unpleasant taste of the drug.
• Suspension prevents degradation or improves the stability of the drug.
• Parenteral suspensions are also applicable in order to control the rate of drug absorption.
• In the cosmetic industry, there are huge applications of suspension. Example-Lotions contain insoluble solid particles to spread a thin coating of medicament on the skin.

Formulation of Suspensions

1. Precipitation Method of Suspension
-Organic solvent precipitation
-Precipitation by pH
-Double decomposition

2. Dispersion Method
3. Controlled Flocculation
4. Structured Vehicle

Advantages of Our Services

• Experienced R&D team, complete production equipment and advanced production facilities.
• Quality, quantity and timely delivery of products with detailed characterization data.
• We will keep the content of the client's commission strictly confidential and can sign a confidentiality agreement if needed.

If you have a requirement about our services, please contact us by phone or email, our colleagues will reply to you within three working days.

References

1. Nikolettos, I., et al. Investigating factors affecting the drug's release from parenteral suspensions. 2015.
2. De Fe Lippis, M. R., and M. J. Akers. Peptides and proteins as parenteral suspensions: An overview of design, development, and manufacturing considerations. 2012.
3. Akers, M. J., A. L. Fites, and R. L. Robison. Formulation design and development of parenteral suspensions. Journal of Parenteral Science & Technology A Publication of the Parenteral Drug Association, 1987, 41(3):88.